{"id":11037,"date":"2022-11-17T02:02:44","date_gmt":"2022-11-16T18:02:44","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11037"},"modified":"2022-11-17T02:02:44","modified_gmt":"2022-11-16T18:02:44","slug":"veibel-stigs-team-published-research-in-acta-chemica-scandinavica-in-1954-cas-27412-71-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11037","title":{"rendered":"Veibel, Stig&#8217;s team published research in Acta Chemica Scandinavica  in 1954 | CAS: 27412-71-1"},"content":{"rendered":"<p>Veibel, Stig published the artcile<b><i>Pyrazole studies. VI. Variation of the basic properties of pyrazolones with substitution in the pyrazolone nucleus<\/i><\/b>,  <a href=\"https:\/\/www.ambeed.com\/products\/27412-71-1.html\">Name:  5-Phenyl-1H-pyrazol-3(2H)-one<\/a>,  the main research area is  .<\/p>\n<p>cf. C.A. 48, 674g. pKB values were determined for a number of pyrazolones by titration with HClO4 in glacial HOAc. The compounds studied (R&#8217;s shown only when other than H), pKB, and m. ps. were: (I), 11.5, 165\u00b0; (II), R3 = Me, 10.9, 216-18\u00b0; (III), R3 = Me3C, 11.1, 200\u00b0; (IV), R3 = Me, R4 = Et, 11.1, 227-8\u00b0; (V), R3 = Me, R4 = C3H7, 11.2, 207-8\u00b0; (VI), R3 = Me, R4 = C3H5, 11.2, 195-6\u00b0; (VII), R3 = Me, R4 = Ph, 11.4, 208-10\u00b0; (VIII), R3 = Ph, 11.4, 232-3\u00b0; (IX), R1 = R3 = Me, 10.3, 117\u00b0 (b19 130\u00b0); (X), R1 = R3 = Me, R4 = Et, 10.5, 94-5\u00b0 (from EtOAc) (b15 137\u00b0); (XI), R1 = R3 = Me, R4 = C3H7, 10.5, 84-5\u00b0 (from EtOAc) (b15 150\u00b0); (XII), R1 = R3 = Me, R4 = C3H5, 10.5, 71-2\u00b0; (XIII), R1 = R3 = Me, R4 = Ph, 10.9, 175\u00b0 (from aqueous MeOH); (XIV), R1 = Me, R3 = Ph, 10.9, 206\u00b0; (XV), R1 = Ph, R3 = Me, 11.3, 127\u00b0; (XVI), R1 = Ph, R3 = Me, R4 = Et, 11.5, 111\u00b0; (XVII), R1 = Ph, R3 = Me, R4 = Pr, 11.4, 101-2\u00b0 (XVIII), R1 = R4 = Ph, R3 = Me, 11.9, 199-200\u00b0; (XIX), R1 = R3 = Ph, 12.2, 137\u00b0; (XXa), R1 = Ph, R3 = Me, R4 = Cl, 13.2, 153\u00b0; (XXb), R1 = Ph, R3 = Me, R4 = Br, 13.3, 122\u00b0; (XXI), R1 = Ph, R2 = R3 = Me, 11.2, 113\u00b0; (XXII), R1 = Ph, R2 = R3 = Me, R4 = Me2CH, 11.6, 101-3\u00b0; (XXIII), R1 = Ph, R3 = Me, R4 = pyrazolonyl, 13.0, decompose; (XXIV), R1 = Ph, R3 = Me, R4 = 3-methyl-5-oxo-1-phenyl-2-oxazolidin-4-ylidenemethyl, 13.8, 185\u00b0; (XXV), R1 = Ph, R3 = Me, R4 = PhCH:CPh, 12.2, 220\u00b0; (XXVI), R3 = Me, R2 = R4 = Et, > 15, 104-5\u00b0; (XXVII), R1 = Ph, R2 = R3 = Me, R4 = Cl, > 15, 68\u00b0; (XXVIII), R1 = Ph, R2 = R4 = Et, R3 = Me, > 15, 161-2\u00b0; (XXIX), R1 = Ph, R4 = Me, 12.2, 167\u00b0; (XXX), R1 = Ph, R3 = Et, R4 = Me, 12.3, 172\u00b0; (XXXI), R1 = R4 = Ph, 12.9, 256\u00b0; (XXXII), R1 = Ph, R2 = R4 = Me, 11.6, 113\u00b0; and (XXXIII), R1 = Ph, R2 = OMe (at C3), R4 = Me, 12.5, b16 154-6\u00b0. Me3CCOCH2CO2Et (7.5 g.), 10 cc. EtOH and 4 cc. 60% N2H4.H2O allowed to stand 2-3 hrs. and filtered gave 4.2 g. III, recrystallized from aqueous EtOH. VII was similarly prepared in 27% yield from AcCHPhCO2Et (XXXIV). In the preparation of IX to XIV, a suspension of 1 mole Ba(OH)2.8H2O in 500 cc. H2O was heated at 100\u00b0, 1 mole N2H4.H2SO4 in 150 cc. H2O at 70\u00b0 added, then 300 cc. H2O, the mixture stirred 1 hr. at 70% filtered, the BaSO4 washed with hot H2O, the combined filtrate and washings made up to 1 l. with H2O; heated with 0.2 mole \u03b1-substituted Et acetoacetate or Et benzoylacetate and 200 cc. N MeNHNH2 at 70\u00b0 for various times, the solution extracted twice with ligroine, the H2O removed at 45-50\u00b0 in vacuo from the aqueous layer, the residue taken up in CHCl3, dried with anhydrous Na2SO4, the CHCl3 evaporated, and the crude pyrazolone purified. The yields of IX to XIV were 51, 60, 65, 50, 70, and 65%, resp., and the reaction time 0.5, 10, 10, 5, 10, and 10 hrs. XXXIV (4 g.) and 2 g. PhNHNH2 heated 1 hr. at 140\u00b0 gave 3.2 g. XVIII. XXV was prepared in 50% yield by heating equimolar amounts of 1-phenyl-3-methylpyrazolin-5-one 3-4 hrs. with PhCH2Bz, filtering, washing the product with Et2O, and recrystallizing from glacial HOAc. The dipole moments of XXXII and XXXIII were determined<\/p>\n<p>Acta Chemica Scandinavica published new progress about Basicity. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, <a href=\"https:\/\/www.ambeed.com\/products\/27412-71-1.html\">Name:  5-Phenyl-1H-pyrazol-3(2H)-one<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acta Chemica Scandinavica published new progress about Basicity. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, <a href=\"https:\/\/www.ambeed.com\/products\/27412-71-1.html\">Name:  5-Phenyl-1H-pyrazol-3(2H)-one<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[678,131],"tags":[717],"class_list":["post-11037","post","type-post","status-publish","format-standard","hentry","category-27412-71-1","category-pyrazoles-derivatives","tag-m-w150-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Veibel, Stig&#039;s team published research in Acta Chemica Scandinavica in 1954 | CAS: 27412-71-1 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Veibel, Stig published the artcilePyrazole studies. 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