{"id":11031,"date":"2022-11-17T02:02:44","date_gmt":"2022-11-16T18:02:44","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=11031"},"modified":"2022-11-17T02:02:44","modified_gmt":"2022-11-16T18:02:44","slug":"guillou-sandrines-team-published-research-in-chemistry-a-european-journal-in-2010-cas-27412-71-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=11031","title":{"rendered":"Guillou, Sandrine’s team published research in Chemistry – A European Journal in 2010 | CAS: 27412-71-1"},"content":{"rendered":"

Guillou, Sandrine published the artcile5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities<\/i><\/b>, Application In Synthesis of 27412-71-1<\/a>, the main research area is substituted pyrazole preparation; arylation; heterocycles; organic synthesis; palladium; pyrazoles.<\/p>\n

Our program, which has focused on the preparation of new pyrazole derivatives, has led us to report here an original and simplified preparation of Et 3-ethoxy-1H-pyrazole-4-carboxylate. This is based on the reaction of hydrazine monohydrochloride and di-Et 2-(ethoxymethylene)malonate. Further transformations of this key compound allowed the preparation of the two possible iodinated isomers, namely, 3-ethoxy-4-iodo- and 3-ethoxy-5-iodo-1H-pyrazole. These compounds have opened the way to a quick access to many original pyrazole series. As an illustration, we report here on the selectivity of N-arylation, by using the Lam and Cham method, the C4- and C5-arylation of some of these 3-ethoxypyrazole derivatives by using the Suzuki-Miyaura reaction, and C5-benzylation reactions by means of the Negishi reaction. This was followed by hydrolysis of the ethoxy group, which led to the corresponding pyrazol-3-one derivatives As a conclusion of this work, we conducted an investigation into the regiochem. of the condensation between di-Et 2-(ethoxymethylene)malonate and the hydrochloride salts of Me, benzyl, or Ph hydrazine.<\/p>\n

Chemistry – A European Journal published new progress about Arylation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Application In Synthesis of 27412-71-1<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Chemistry – A European Journal published new progress about Arylation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Application In Synthesis of 27412-71-1<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[678,131],"tags":[717],"class_list":["post-11031","post","type-post","status-publish","format-standard","hentry","category-27412-71-1","category-pyrazoles-derivatives","tag-m-w150-200"],"yoast_head":"\nGuillou, Sandrine's team published research in Chemistry - A European Journal in 2010 | CAS: 27412-71-1 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Guillou, Sandrine published the artcile5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities, Application In Synthesis of 27412-71-1, the main research area is substituted pyrazole preparation; arylation; heterocycles; organic synthesis; palladium; pyrazoles.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11031\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Guillou, Sandrine's team published research in Chemistry - A European Journal in 2010 | CAS: 27412-71-1 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Guillou, Sandrine published the artcile5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities, Application In Synthesis of 27412-71-1, the main research area is substituted pyrazole preparation; arylation; heterocycles; organic synthesis; palladium; pyrazoles.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=11031\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-16T18:02:44+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11031\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11031\",\"name\":\"Guillou, Sandrine's team published research in Chemistry - A European Journal in 2010 | CAS: 27412-71-1 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-16T18:02:44+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Guillou, Sandrine published the artcile5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities, Application In Synthesis of 27412-71-1, the main research area is substituted pyrazole preparation; arylation; heterocycles; organic synthesis; palladium; pyrazoles.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11031#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=11031\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=11031#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Guillou, Sandrine’s team published research in Chemistry – A European Journal in 2010 | CAS: 27412-71-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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