{"id":1101,"date":"2020-11-24T10:53:21","date_gmt":"2020-11-24T02:53:21","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1101"},"modified":"2020-11-24T10:53:21","modified_gmt":"2020-11-24T02:53:21","slug":"research-on-new-synthetic-routes-about-ethyl-1h-pyrazole-3-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1101","title":{"rendered":"Research on new synthetic routes about Ethyl 1H-pyrazole-3-carboxylate"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., 5932-27-4<\/a><\/p>\n

Description 14; Ethyl 1 -{[4-(5-{3-chloro-4-[(1 -methylethyl)oxy]phenyl}-1 ,2,4-oxadiazol-3- yl)phenyl]methyl}-1H-pyrazole-3-carboxylate (D14); [4-(5-{3-Chloro-4-[(1-methylethyl)oxy]phenyl}-1 ,2,4-oxadiazol-3-yl)phenyl]methanol (D13) (200 mg) and ethyl 1 H-pyrazole-3-carboxylate (D1 ) (85 mg) were dissolved in toluene (4.6 ml) under an Ar atmosphere and treated with tributylphosphine (152 mul). After stirring for 5 minutes 1 ,1′-azobis(N,N-dimethylformamide) (105 mg) was added and stirring continued overnight. The reaction mixture was then filtered, washing with toluene, and evaporated to dryness. The residue was purified by flash chromatography on silica, eluting with a 0-100 percent EtOAc in pentane to give the undesired isomer (86 mg) and the title compound (108 mg) in poor purity. deltaH (CDCI3, 400MHz): 1.42 (3H, t), 1.45 (6H, d), 4.43 (2H, q), 4.72 (1 H, quintet), 5.48 (2H, s), 6.87 (1 H, d), 7.06 (1 H, d), 7.36 (2H, d), 7.41 (1 H, d), 8.05 (1 H, dd), 8.14 (2H, d), 8.23 (1 H, d). MS (ES): C24H23CIN4O4 requires 466.92; found 467 (M+H).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[170,131],"tags":[126],"class_list":["post-1101","post","type-post","status-publish","format-standard","hentry","category-5932-27-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about Ethyl 1H-pyrazole-3-carboxylate<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., 5932-27-4\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1101\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on new synthetic routes about Ethyl 1H-pyrazole-3-carboxylate\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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