{"id":10998,"date":"2022-11-16T03:23:12","date_gmt":"2022-11-15T19:23:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10998"},"modified":"2022-11-16T03:23:12","modified_gmt":"2022-11-15T19:23:12","slug":"hansen-joshua-d-s-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-2008-08-15-cas-166196-54-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10998","title":{"rendered":"Hansen, Joshua D.’s team published research in Bioorganic & Medicinal Chemistry Letters in 2008-08-15 | CAS: 166196-54-9"},"content":{"rendered":"

Hansen, Joshua D. published the artcilePotent and selective pyrazole-based inhibitors of B-Raf kinase<\/i><\/b>, Recommanded Product: 4-(4-Bromo-1H-pyrazol-3-yl)pyridine<\/a>, the main research area is pyrazole derivative inhibitor B Raf kinase antitumor.<\/p>\n

Herein we describe a novel pyrazole-based class of ATP competitive B-Raf inhibitors. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. A subset of these inhibitors has demonstrated the ability to inhibit downstream ERK phosphorylation in LOX tumors from mouse xenograft studies.<\/p>\n

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 166196-54-9 belongs to class pyrazoles-derivatives, name is 4-(4-Bromo-1H-pyrazol-3-yl)pyridine, and the molecular formula is C8H6BrN3, Recommanded Product: 4-(4-Bromo-1H-pyrazol-3-yl)pyridine<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 166196-54-9 belongs to class pyrazoles-derivatives, name is 4-(4-Bromo-1H-pyrazol-3-yl)pyridine, and the molecular formula is C8H6BrN3, Recommanded Product: 4-(4-Bromo-1H-pyrazol-3-yl)pyridine<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[783,131],"tags":[716],"class_list":["post-10998","post","type-post","status-publish","format-standard","hentry","category-166196-54-9","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nHansen, Joshua D.'s team published research in Bioorganic & Medicinal Chemistry Letters in 2008-08-15 | CAS: 166196-54-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Hansen, Joshua D. published the artcilePotent and selective pyrazole-based inhibitors of B-Raf kinase, Recommanded Product: 4-(4-Bromo-1H-pyrazol-3-yl)pyridine, the main research area is pyrazole derivative inhibitor B Raf kinase antitumor.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10998\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hansen, Joshua D.'s team published research in Bioorganic & Medicinal Chemistry Letters in 2008-08-15 | CAS: 166196-54-9 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Hansen, Joshua D. published the artcilePotent and selective pyrazole-based inhibitors of B-Raf kinase, Recommanded Product: 4-(4-Bromo-1H-pyrazol-3-yl)pyridine, the main research area is pyrazole derivative inhibitor B Raf kinase antitumor.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10998\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-15T19:23:12+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10998\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10998\",\"name\":\"Hansen, Joshua D.'s team published research in Bioorganic & Medicinal Chemistry Letters in 2008-08-15 | CAS: 166196-54-9 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-11-15T19:23:12+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Hansen, Joshua D. published the artcilePotent and selective pyrazole-based inhibitors of B-Raf kinase, Recommanded Product: 4-(4-Bromo-1H-pyrazol-3-yl)pyridine, the main research area is pyrazole derivative inhibitor B Raf kinase antitumor.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10998#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10998\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10998#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hansen, Joshua D.’s team published research in Bioorganic & Medicinal Chemistry Letters in 2008-08-15 | CAS: 166196-54-9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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