{"id":10971,"date":"2022-11-15T03:38:41","date_gmt":"2022-11-14T19:38:41","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10971"},"modified":"2022-11-15T03:38:41","modified_gmt":"2022-11-14T19:38:41","slug":"nwankwoala-reginaid-n-p-s-team-published-research-in-research-journal-of-medicine-and-medical-sciences-in-2009-12-31-cas-1691-93-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10971","title":{"rendered":"Nwankwoala, Reginaid N. P.’s team published research in Research Journal of Medicine and Medical Sciences in 2009-12-31 | CAS: 1691-93-6"},"content":{"rendered":"

Nwankwoala, Reginaid N. P. published the artcileAnti inflammatory property of new pyrazolon derivatives<\/i><\/b>, Safety of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one<\/a>, the main research area is antiinflammatory inflammation pyrazolone derivative phenylbutazone.<\/p>\n

The anti inflammatory effects of 4-trifluoroacety1-1-pheny1-3-methy1 pyrazolone (HTFP) and 4-sebacyl-1-bis 1-pheny1-3-methy1 pyrazolone (HSP) were investigated and compared with those of phenylbutazone (PTZ) using carrageenan-induced paw inflammation model in rats. Different doses of PTZ, HTFP and HSP were intra-peritoneally administered to rats and one hour thereafter, inflammation was induced by injecting carrageenan into the left foot of the rat. The right foot received saline. Five (5) rats received carrageenan and saline only. Both the left and right feet were measured hourly for four hours. PTZ, HTFP and HSP significantly reduced carrageenan induced inflammation. 100Mg\/kg PTZ caused 62.5 \u00b1 5.25% reduction of the inflammatory response whereas 10mg\/kg HTFP and 10mg\/kg HSP reduced inflammatory response by 53.6 \u00b1 5.0% and 32.5 \u00b1 4.50% resp. Thus anti-inflammatory properties of these drugs were less at lower doses. These results show that (1) HTFP and HSP possess anti-inflammatory property, (2) HTFP is more potent than HSP and (3) The anti-inflammatory potency of phenylbutazone drug is greatly enhanced by substitution of trifluoroacety1-1-group at position 4 of the pyrazolone mol.<\/p>\n

Research Journal of Medicine and Medical Sciences published new progress about Anti-inflammatory agents. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Safety of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Research Journal of Medicine and Medical Sciences published new progress about Anti-inflammatory agents. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Safety of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[775,131],"tags":[740],"class_list":["post-10971","post","type-post","status-publish","format-standard","hentry","category-1691-93-6","category-pyrazoles-derivatives","tag-m-w250-300"],"yoast_head":"\nNwankwoala, Reginaid N. P.'s team published research in Research Journal of Medicine and Medical Sciences in 2009-12-31 | CAS: 1691-93-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Nwankwoala, Reginaid N. 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