{"id":10913,"date":"2022-11-02T11:02:20","date_gmt":"2022-11-02T03:02:20","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10913"},"modified":"2022-11-02T11:02:20","modified_gmt":"2022-11-02T03:02:20","slug":"naim-mohd-javed-et-al-published-their-research-in-bioorganic-chemistry-in-2017-cas-36640-53-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10913","title":{"rendered":"Naim, Mohd. Javed et al. published their research in Bioorganic Chemistry in 2017 |CAS: 36640-53-6"},"content":{"rendered":"

On August 31, 2017, Naim, Mohd. Javed; Alam, Jahangir Md.; Nawaz, Farah; Naidu, V. G. M.; Aaghaz, Shams; Sahu, Meeta; Siddiqui, Nadeem; Alam, Ozair published an article.SDS of cas: 36640-53-6<\/a> The title of the article was Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives. And the article contained the following:<\/p>\n

A series of thiazolidinedione based amide derivatives were designed, synthesized and docked against the PPAR\u03b3 receptor target. 11 Compounds from the series with good glide scores were selected for in vivo antidiabetic study based on streptozotocin induced diabetic rat model. It was observed that 4 compounds (I, II, III & IV) showed significantly good antidiabetic activity in comparison to rosiglitazone and pioglitazone as reference drugs. Compound I appeared as the most potent derivative in lowering blood glucose level and showed excellent interaction with SER 342, ILE 281, pi-pi interaction with ARG 288 and halogen bond interaction with LYS 367. Further, PPAR\u03b3 transactivation and gene expression studies of compound I were carried out to investigate the possible mechanism of action through PPAR\u03b3 modulation. Compound I exhibited 53.65% transactivation and elevated PPAR\u03b3 gene expression by 2.1 folds. The biochem. parameters (AST, ALT and ALP levels) were found within the range with no noteworthy damage to liver. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).SDS of cas: 36640-53-6<\/a><\/p>\n

The Article related to thiazolidinedione amide derivative synthesis sar antidiabetic pharmacokinetics toxicity, antidiabetic, molecular docking, ppar\u03b3, thiazolidinedione, Pharmacology: Structure-Activity and other aspects.SDS of cas: 36640-53-6<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Article related to thiazolidinedione amide derivative synthesis sar antidiabetic pharmacokinetics toxicity, antidiabetic, molecular docking, ppar\u03b3, thiazolidinedione, Pharmacology: Structure-Activity and other aspects.SDS of cas: 36640-53-6<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[762,131],"tags":[129],"class_list":["post-10913","post","type-post","status-publish","format-standard","hentry","category-36640-53-6","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nNaim, Mohd. Javed et al. published their research in Bioorganic Chemistry in 2017 |CAS: 36640-53-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On August 31, 2017, Naim, Mohd. Javed; Alam, Jahangir Md.; Nawaz, Farah; Naidu, V. G. M.; Aaghaz, Shams; Sahu, Meeta; Siddiqui, Nadeem; Alam, Ozair published an article.SDS of cas: 36640-53-6 The title of the article was Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives. And the article contained the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10913\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Naim, Mohd. Javed et al. published their research in Bioorganic Chemistry in 2017 |CAS: 36640-53-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"On August 31, 2017, Naim, Mohd. Javed; Alam, Jahangir Md.; Nawaz, Farah; Naidu, V. G. 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