{"id":10896,"date":"2022-11-02T11:01:04","date_gmt":"2022-11-02T03:01:04","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10896"},"modified":"2022-11-02T11:01:04","modified_gmt":"2022-11-02T03:01:04","slug":"liu-bo-et-al-published-their-patent-in-2021-cas-2089292-88-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10896","title":{"rendered":"Liu, Bo et al. published their patent in 2021 |CAS: 2089292-88-4"},"content":{"rendered":"

On June 24, 2021, Liu, Bo; Cotesta, Simona; Gerspacher, Marc; Leblanc, Catherine; Lorthiois, Edwige Liliane Jeanne; Machauer, Rainer; Mah, Robert; Mura, Christophe; Rigollier, Pascal; Schneider, Nadine; Stutz, Stefan; Vaupel, Andrea; Warin, Nicolas; Wilcken, Rainer published a patent.Product Details of 2089292-88-4<\/a> The title of the patent was Pyrazole derivatives as anti-cancer agents and preparation. And the patent contained the following:<\/p>\n

The invention relates compounds of formula I, us as anti-cancer agents in the ability to inhibit KRASG12C and their preparation Compound I, wherein A is (un)substituted C5-7, (un)substituted C5-10, (un)substituted 5- to 7-membered unsaturated heterocyclyl containing one carbon-carbon double bond and one oxygen, etc.; B selected from the group of B1 and B2; B1 is (un)substituted C6-10 with 1, 2, 3 and 4 RBa; B2 is 6- to 13-membered heteroaryl containing 1, 2 and 3 nitrogen atoms and is (un)substituted 1, 2, 3 and 4 RBb; each RBa is independently hydroxy, C1-4 alkyl, halo, etc.; each RBb is independently C1-4 alkyl; cyclopropyl, halo, etc.; C is hydrogen, C1-3 alkyl, C3-5 cycloalkyl, etc.; L is (un)substituted 2-azaspiro[3.3]heptanyl, (un)substituted 2-azaspiro[3.4]heptanyl, pyrrolidine, etc.; D is (un)substituted prop-2-en-1-one, (un)substituted prop-2-yn-1-one, etc.; and stereoisomers, atropisomers, pharmaceutically acceptable salts, thereof, are claimed. Conmpound II was prepared using a multistep procedure (procedure given). Compound II was evaluated for KRAS G12C inhibitory activity yielding an IC50 of 0.017\u03bcM. Compounds of the invention were evaluated for KRAS G12C inhibitory activity (data given). The experimental process involved the reaction of 5-Bromo-2-methyl-2H-pyrazolo[3,4-c]pyridine(cas: 2089292-88-4).Product Details of 2089292-88-4<\/a><\/p>\n

The Article related to pyrazole preparation cancer kras inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 2089292-88-4<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Article related to pyrazole preparation cancer kras inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 2089292-88-4<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[769,131],"tags":[129],"class_list":["post-10896","post","type-post","status-publish","format-standard","hentry","category-2089292-88-4","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nLiu, Bo et al. published their patent in 2021 |CAS: 2089292-88-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On June 24, 2021, Liu, Bo; Cotesta, Simona; Gerspacher, Marc; Leblanc, Catherine; Lorthiois, Edwige Liliane Jeanne; Machauer, Rainer; Mah, Robert; Mura, Christophe; Rigollier, Pascal; Schneider, Nadine; Stutz, Stefan; Vaupel, Andrea; Warin, Nicolas; Wilcken, Rainer published a patent.Product Details of 2089292-88-4 The title of the patent was Pyrazole derivatives as anti-cancer agents and preparation. 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