{"id":1089,"date":"2020-11-23T11:00:31","date_gmt":"2020-11-23T03:00:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1089"},"modified":"2020-11-23T11:00:31","modified_gmt":"2020-11-23T03:00:31","slug":"the-origin-of-a-common-compound-about-1-methyl-1h-pyrazole-3-sulfonyl-chloride","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1089","title":{"rendered":"The origin of a common compound about 1-Methyl-1H-pyrazole-3-sulfonyl chloride"},"content":{"rendered":"

89501-90-6<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89501-90-6 name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

2-(3-(5-Amino-6-(azetidin-3-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol hydrochloride salt (0.010 g, 0.025 mmol) in DCM (0.25 mL) was treated with DIPEA (0.026 mL, 0.15 mmol) and 1-methyl-1H-pyrazole-3-sulfonyl chloride (4.5 mg, 0.025 mmol, Maybridge). After 1 hour, the reaction was quenched by the addition of a small quantity of water and ammonium hydroxide solution. The mixture was concentrated via rotary evaporation to remove DCM and the mixture was diluted with MeOH and purified by preparative HPLC-MS (pH=10) to afford the title compound (enriched in one enantiomer, believed to be (S)-, see stereochemical rationale supra) (5 mg, 40%). LCMS calculated for C21H24F3N6O4S (M+H)+: m\/z=513.2, found: 513.1. 1H NMR (400 MHz, MeOD) delta 7.93-7.90 (s, 1H), 7.63-7.59 (d, J=2.0 Hz, 1H), 7.59-7.55 (d, J=8.0 Hz, 1H), 7.40-7.35 (m, 2H), 6.84-6.50 (d, J=2.3 Hz, 1H), 4.28-4.24 (m, 4H), 4.14-4.09 (d, J=11.8 Hz, 1H), 4.09-4.05 (d, J=11.8 Hz, 1H), 4.03-3.94 (p, J=8.1 Hz, 1H), 3.56-3.46 (s, 3H), 2.36-2.14 (s, 3H). 19F NMR (376 MHz, MeOD) delta -78.08–78.59 (s).<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-3-sulfonyl chloride, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-3-sulfonyl chloride, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[181,131],"tags":[126],"class_list":["post-1089","post","type-post","status-publish","format-standard","hentry","category-89501-90-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe origin of a common compound about 1-Methyl-1H-pyrazole-3-sulfonyl chloride<\/title>\n<meta name=\"description\" content=\"89501-90-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89501-90-6 name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1089\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The origin of a common compound about 1-Methyl-1H-pyrazole-3-sulfonyl chloride\" \/>\n<meta property=\"og:description\" content=\"89501-90-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89501-90-6 name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The origin of a common compound about 1-Methyl-1H-pyrazole-3-sulfonyl chloride","description":"89501-90-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89501-90-6 name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=1089","og_locale":"en_US","og_type":"article","og_title":"The origin of a common compound about 1-Methyl-1H-pyrazole-3-sulfonyl chloride","og_description":"89501-90-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89501-90-6 name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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