{"id":10887,"date":"2022-11-02T11:01:04","date_gmt":"2022-11-02T03:01:04","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10887"},"modified":"2022-11-02T11:01:04","modified_gmt":"2022-11-02T03:01:04","slug":"rainer-georg-et-al-published-their-patent-in-1972-cas-36640-53-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10887","title":{"rendered":"Rainer, Georg et al. published their patent in 1972 |CAS: 36640-53-6"},"content":{"rendered":"

On February 24, 1972, Rainer, Georg; Riedel, Richard published a patent.Formula: C20H14N2O<\/a> The title of the patent was 4-(Hydroxymethyl)- and 4-formyl-1-arylpyrazoles. And the patent contained the following:<\/p>\n

Thirty title compounds [I, R = CHO or CH2OH; R1 = (substituted) phenyl, 3-pyridyl, 2-furyl, or 2-naphthyl; R2 = H, F, Cl, Br, Me, or MeO], useful as intermediates for pharmaceutical 4-(carboxymethyl)- or 4-(cyanomethyl)-1-arylpyrazoles, were prepared by reacting R1CMe:NNHC6H4R2-p with DMF and POCl3 via I (R = CH:N+Me2ClO4-) (Ia). Saponifying Ia gave I (R = CHO), which on reduction gave I (R = CH2OH). Thus, POCl3 was stirred 1 hr with DMF and treated with p-ClC6H4CMe:NNHPh 6 hr at 70\u00b0. The mixture was treated 5 hr with aqueous NaOH at pH 7 to give 99% I (R = CHO, R1 = C6H4Cl-p, R2 = H) (II). II was treated in EtOH and DMF with NaBH4 1 hr at 20-5\u00b0 to give 93% I (R = CH2OH, R1 = C6H4Cl-p, R2 = H). The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Formula: C20H14N2O<\/a><\/p>\n

The Article related to pyrazolecarboxaldehyde, hydroxymethylpyrazole, benzenes pyrazolyl, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C20H14N2O<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Article related to pyrazolecarboxaldehyde, hydroxymethylpyrazole, benzenes pyrazolyl, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C20H14N2O<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[762,131],"tags":[129],"class_list":["post-10887","post","type-post","status-publish","format-standard","hentry","category-36640-53-6","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nRainer, Georg et al. published their patent in 1972 |CAS: 36640-53-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On February 24, 1972, Rainer, Georg; Riedel, Richard published a patent.Formula: C20H14N2O The title of the patent was 4-(Hydroxymethyl)- and 4-formyl-1-arylpyrazoles. 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