{"id":10885,"date":"2022-11-02T11:01:04","date_gmt":"2022-11-02T03:01:04","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10885"},"modified":"2022-11-02T11:01:04","modified_gmt":"2022-11-02T03:01:04","slug":"blake-james-et-al-published-their-patent-in-2009-cas-924909-16-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10885","title":{"rendered":"Blake, James et al. published their patent in 2009 |CAS: 924909-16-0"},"content":{"rendered":"

On July 16, 2009, Blake, James; Gunawardana, Indrani W.; Le Huerou, Yvan; Mohr, Peter J.; Wallace, Eli M.; Wang, Bin published a patent.Computed Properties of 924909-16-0<\/a> The title of the patent was Pyrazolopyridine derivatives and their pharmaceutical compositions as CHK1 and CHK2 kinase inhibitors for the treatment of various diseases and preparation thereof. And the patent contained the following:<\/p>\n

Title compounds I and II, their pharmaceutical compositions, and their pharmaceutically acceptable salts, are prepared and disclosed as inhibitors of CHK1 and CHK2 kinases and useful in the treatment of diseases mediated by said kinases. Compounds of formula I [m, n, p independently = 0 or 1; G = (un)substituted Ph when m = 1, or G = absent, alkyl, or (un)substituted Ph when m = 0; R1 = H, alkyl, haloalkyl, etc.; R2 = H, CF3, (un)substituted alkenyl, etc., with the provision that when R1 = H, then R2 = OR14; R14 = alkyl optionally substituted with 1 or more OH; R3, R7, and R8 independently = H or alkyl; R5, R6, and R9 independently = H or Me] and II [Q = CH2 or CH2CH2; R15 and R16 independently = H or alkyl], their pharmaceutical compositions, and their pharmaceutically acceptable salts, are claimed. For example, compound III\u00b72HCl was prepared via amidation of (S)-3-(tert-butoxycarbonyl(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid with 5-phenyl-4-(piperazin-1-yl)-1H-pyrazolo[3,4-b]pyridine dihydrochloride, followed by removal of the BOC protecting group. Select I and II were assayed for CHK1 kinase activity and found to possess IC50 values of <10 \u03bcM. The experimental process involved the reaction of 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol(cas: 924909-16-0).Computed Properties of 924909-16-0<\/a><\/p>\n

The Article related to pyrazolopyridine derivative preparation chk1 chk2 kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 924909-16-0<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Article related to pyrazolopyridine derivative preparation chk1 chk2 kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 924909-16-0<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[767,131],"tags":[129],"class_list":["post-10885","post","type-post","status-publish","format-standard","hentry","category-924909-16-0","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nBlake, James et al. published their patent in 2009 |CAS: 924909-16-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On July 16, 2009, Blake, James; Gunawardana, Indrani W.; Le Huerou, Yvan; Mohr, Peter J.; Wallace, Eli M.; Wang, Bin published a patent.Computed Properties of 924909-16-0 The title of the patent was Pyrazolopyridine derivatives and their pharmaceutical compositions as CHK1 and CHK2 kinase inhibitors for the treatment of various diseases and preparation thereof. 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