{"id":10867,"date":"2022-11-02T10:59:43","date_gmt":"2022-11-02T02:59:43","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10867"},"modified":"2022-11-02T10:59:43","modified_gmt":"2022-11-02T02:59:43","slug":"xu-zichen-et-al-published-their-patent-in-2019-cas-1187582-58-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10867","title":{"rendered":"Xu, Zichen et al. published their patent in 2019 |CAS: 1187582-58-6"},"content":{"rendered":"<p>On December 20, 2019, Xu, Zichen; Wei, Wanguo; Fang, Xianjie; Liu, Rufeng; Yi, Mingyue; Zhou, Chenglong; Liu, Jie published a patent.<a href=\"https:\/\/www.ambeed.com\/products\/1187582-58-6.html\">Computed Properties of  1187582-58-6<\/a> The title of the patent was Preparation method of N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide as androgen receptor antagonist. And the patent contained the following:<\/p>\n<p>The invention relates to a process for the preparation of N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide as androgen receptor antagonist. For instance, Suzuki reaction of 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzonitrile with 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole followed by deprotection, N-alkylation with N-Boc-L-alaninol, amidation with 5-acetyl-1H-pyrazole-3-carboxylic acid Et ester, and reduction to give N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide. The experimental process involved the reaction of 5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole(cas: 1187582-58-6).<a href=\"https:\/\/www.ambeed.com\/products\/1187582-58-6.html\">Computed Properties of  1187582-58-6<\/a><\/p>\n<p>The Article related to chlorocyanophenyl pyrazolylmethylethylhydroxyethyl pyrazolecarboxamide preparation suzuki alkylation amidation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/1187582-58-6.html\">Computed Properties of  1187582-58-6<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to chlorocyanophenyl pyrazolylmethylethylhydroxyethyl pyrazolecarboxamide preparation suzuki alkylation amidation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/1187582-58-6.html\">Computed Properties of  1187582-58-6<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[766,131],"tags":[129],"class_list":["post-10867","post","type-post","status-publish","format-standard","hentry","category-1187582-58-6","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Xu, Zichen et al. published their patent in 2019 |CAS: 1187582-58-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On December 20, 2019, Xu, Zichen; Wei, Wanguo; Fang, Xianjie; Liu, Rufeng; Yi, Mingyue; Zhou, Chenglong; Liu, Jie published a patent.Computed Properties of 1187582-58-6 The title of the patent was Preparation method of N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide as androgen receptor antagonist. 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