{"id":10850,"date":"2022-11-02T10:58:18","date_gmt":"2022-11-02T02:58:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10850"},"modified":"2022-11-02T10:58:18","modified_gmt":"2022-11-02T02:58:18","slug":"cottam-howard-b-et-al-published-their-research-in-nucleic-acids-research-in-1983-cas-85426-79-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10850","title":{"rendered":"Cottam, Howard B. et al. published their research in Nucleic Acids Research in 1983 |CAS: 85426-79-5"},"content":{"rendered":"<p>On February 11, 1983, Cottam, Howard B.; Revankar, Ganapathi R.; Robins, Roland K. published an article.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">HPLC of Formula: 85426-79-5<\/a> The title of the article was A convenient synthesis of 6-amino-1-\u03b2-D-ribofuranosylpyrazolo[3,4-d]pyrimidin-4-one and related 4,6-disubstituted pyrazolopyrimidine nucleosides. And the article contained the following:<\/p>\n<p>The glycosylation of 4,6-dichloropyrazolo[3,4-d]pyrimidine and 4-chloro-6-methylthiopyrazolo[3,4-d]pyrimidine via the corresponding trimethylsilyl intermediate and tetra-O-acetyl-\u03b2-D-ribofuranose in the presence of trimethylsilyl triflate as a catalyst, gave selective glycosylation at N-1 as the only nucleoside product. The intermediates 4,6-dichloro-1-(2,3,5-tri-O-acetyl-\u03b2-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine and 4-chloro-6-methylthio-1-(2,3,5-tri-O-acetyl-\u03b2-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine gave new and convenient synthetic routes to the inosine analog I, the guanosine analog II, the adenosine analog III, and the isoguanosine analog IV. Glycosylation of the trimethylsilyl derivative of 6-chloropyrazolo[3,4-d]pyrimidin-4-one unexpectedly gave the N-2 glycosyl isomer as the major product. A number of new 4,6-disubstituted pyrazolo[3,4-d]pyrimidine nucleosides were prepared from these glycosyl intermediates. The experimental process involved the reaction of 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(cas: 85426-79-5).<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">HPLC of Formula: 85426-79-5<\/a><\/p>\n<p>The Article related to pyrazolopyrimidine nucleoside, ribofuranosylpyrazolopyrimidinone, glycosylation pyrazolopyrimidine ribofuranose, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">HPLC of Formula: 85426-79-5<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to pyrazolopyrimidine nucleoside, ribofuranosylpyrazolopyrimidinone, glycosylation pyrazolopyrimidine ribofuranose, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">HPLC of Formula: 85426-79-5<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[765,131],"tags":[129],"class_list":["post-10850","post","type-post","status-publish","format-standard","hentry","category-85426-79-5","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cottam, Howard B. et al. published their research in Nucleic Acids Research in 1983 |CAS: 85426-79-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On February 11, 1983, Cottam, Howard B.; Revankar, Ganapathi R.; Robins, Roland K. published an article.HPLC of Formula: 85426-79-5 The title of the article was A convenient synthesis of 6-amino-1-\u03b2-D-ribofuranosylpyrazolo[3,4-d]pyrimidin-4-one and related 4,6-disubstituted pyrazolopyrimidine nucleosides. 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