{"id":10842,"date":"2022-11-02T10:58:18","date_gmt":"2022-11-02T02:58:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10842"},"modified":"2022-11-02T10:58:18","modified_gmt":"2022-11-02T02:58:18","slug":"vignaroli-giulia-et-al-published-their-research-in-acs-combinatorial-science-in-2014-cas-85426-79-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10842","title":{"rendered":"Vignaroli, Giulia et al. published their research in ACS Combinatorial Science in 2014 |CAS: 85426-79-5"},"content":{"rendered":"<p>On April 14, 2014, Vignaroli, Giulia; Mencarelli, Martina; Sementa, Deborah; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni; Schenone, Silvia; Radi, Marco; Botta, Maurizio published an article.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Name: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine<\/a> The title of the article was Exploring the Chemical Space around the Privileged Pyrazolo[3,4-d]pyrimidine Scaffold: Toward Novel Allosteric Inhibitors of T315I-Mutated Abl. And the article contained the following:<\/p>\n<p>A library of pyrazolo[3,4-d]pyrimidines, endowed with a high level of mol. diversity, has been developed applying a synthetic sequence that allowed C3, N1, C4, and C6 substitution. The enzymic screening of this &#8220;privileged scaffold&#8221;-based compound collection, validated the use of a diversity-oriented approach in a field characteristically explored by target-oriented synthesis. In fact, several compounds showed high activity against the selected kinases (i.e., Src, Abl wt, and T315I mutated-form), furthermore and interestingly a new compound has emerged as an allosteric inhibitor of the T315I mutated-form of Abl, opening up new opportunities for the development of a novel class of noncompetitive inhibitors of Abl (T315I). The experimental process involved the reaction of 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(cas: 85426-79-5).<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Name: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine<\/a><\/p>\n<p>The Article related to diversity oriented synthesis library pyrazolopyrimidine inhibitor src abl kinase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Name: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to diversity oriented synthesis library pyrazolopyrimidine inhibitor src abl kinase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Name: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[765,131],"tags":[129],"class_list":["post-10842","post","type-post","status-publish","format-standard","hentry","category-85426-79-5","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vignaroli, Giulia et al. published their research in ACS Combinatorial Science in 2014 |CAS: 85426-79-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On April 14, 2014, Vignaroli, Giulia; Mencarelli, Martina; Sementa, Deborah; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni; Schenone, Silvia; Radi, Marco; Botta, Maurizio published an article.Name: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine The title of the article was Exploring the Chemical Space around the Privileged Pyrazolo[3,4-d]pyrimidine Scaffold: Toward Novel Allosteric Inhibitors of T315I-Mutated Abl. 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