{"id":1083,"date":"2020-11-23T11:00:31","date_gmt":"2020-11-23T03:00:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1083"},"modified":"2020-11-23T11:00:31","modified_gmt":"2020-11-23T03:00:31","slug":"the-important-role-of-1124-16-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1083","title":{"rendered":"The important role of 1124-16-9"},"content":{"rendered":"

1124-16-9<\/a>, The chemical industry reduces the impact on the environment during synthesis 1124-16-9, name is 5-Amino-1-isopropyl-3-methylpyrazole, I believe this compound will play a more active role in future production and life.<\/p>\n

Hydrochloric acid in 1,4-dioxane (1.25 mL, 5.00 mmol, 4 mol\/L) followed by 1,1′- thiocarbonyldiimidazole (520.1 mg, 2.773 mmol) were added to a stirred solution of l-isopropyl-3- methyl-lH-pyrazol-5-amine [1124-16-9] (368.2 mg, 2.513 mmol) in DCM (7.5 mL) under nitrogen. (2488) The reaction mixture was stirred at rt for 19 h. The reaction mixture was filtered and the white solid was washed with DCM (2 x 15 mL). The filtrate and washings were concentrated in vacuo to give a golden yellow oil which was purified by flash column chromatography on silica (gradient elution with 0% to 50% EtOAc in isohexane) to afford the title compound (167.6 mg, 0.9246 mmol, 37%) as a pale yellow liquid. To confirm the presence of the title compound, a few drops of isobutylamine were added to the LCMS sample of the product before analysis to give the thiourea, LCMS [M+H]+ 255.1, RT 1.256 minutes, purity 99.6% (Method 15).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 1124-16-9. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 1124-16-9. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[204,131],"tags":[126],"class_list":["post-1083","post","type-post","status-publish","format-standard","hentry","category-1124-16-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 1124-16-9<\/title>\n<meta name=\"description\" content=\"1124-16-9, The chemical industry reduces the impact on the environment during synthesis 1124-16-9, name is 5-Amino-1-isopropyl-3-methylpyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1083\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 1124-16-9\" \/>\n<meta property=\"og:description\" content=\"1124-16-9, The chemical industry reduces the impact on the environment during synthesis 1124-16-9, name is 5-Amino-1-isopropyl-3-methylpyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1083\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-23T03:00:31+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1083\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1083\",\"name\":\"The important role of 1124-16-9\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-11-23T03:00:31+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"1124-16-9, The chemical industry reduces the impact on the environment during synthesis 1124-16-9, name is 5-Amino-1-isopropyl-3-methylpyrazole, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1083#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1083\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1083#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The important role of 1124-16-9\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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