{"id":10808,"date":"2022-11-02T03:24:18","date_gmt":"2022-11-01T19:24:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10808"},"modified":"2022-11-02T03:24:18","modified_gmt":"2022-11-01T19:24:18","slug":"brenneman-jehrod-burnett-et-al-published-their-patent-in-2020-cas-98138-75-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10808","title":{"rendered":"Brenneman, Jehrod Burnett et al. published their patent in 2020 |CAS: 98138-75-1"},"content":{"rendered":"<p>On June 25, 2020, Brenneman, Jehrod Burnett; Krall, Elsa Beyer; Schlabach, Michael; Wylie, Andrew Alistair published a patent.<a href=\"https:\/\/www.ambeed.com\/products\/98138-75-1.html\">Recommanded Product: 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine<\/a> The title of the patent was Preparation of substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors. And the patent contained the following:<\/p>\n<p>The present disclosure provides compounds having formula I and the pharmaceutically acceptable salts and solvates thereof, wherein X1, X2 is independently N and CR2; R1 and R2 are independently H, halo, cyano, (un)substituted alkyl, etc.; R3 is (un)substituted Ph, pyridinyl, pyrazolyl, etc.; X11 and X12 is independently N and CH; R5&#8242; is H, (un)substituted C1-6alkyl, (un)substituted C1-6alkoxy, etc.; R5 is (un)substituted C1-6alkyl, (un)substituted C2-6alkenyl, C1-6haloalkyl, etc.; R6 and R7 is independently H, halo, CN, (un)substituted alkenyl, etc. The present disclosure is also directed to the use of compounds of Formula I to inhibit a USP1 protein and to treat a disorder responsive to the inhibition of USP1 proteins and USP1 activity. Example compound II was prepared via a multistep procedure (procedure given). From the assay, it was determined that example compound II exhibited IC50 value of > 200 nM towards USP1. The experimental process involved the reaction of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine(cas: 98138-75-1).<a href=\"https:\/\/www.ambeed.com\/products\/98138-75-1.html\">Recommanded Product: 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine<\/a><\/p>\n<p>The Article related to pyrazolopyrimidines purine preparation usp1 inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/98138-75-1.html\">Recommanded Product: 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to pyrazolopyrimidines purine preparation usp1 inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/98138-75-1.html\">Recommanded Product: 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[764,131],"tags":[128],"class_list":["post-10808","post","type-post","status-publish","format-standard","hentry","category-98138-75-1","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Brenneman, Jehrod Burnett et al. published their patent in 2020 |CAS: 98138-75-1 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On June 25, 2020, Brenneman, Jehrod Burnett; Krall, Elsa Beyer; Schlabach, Michael; Wylie, Andrew Alistair published a patent.Recommanded Product: 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine The title of the patent was Preparation of substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors. 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