{"id":10793,"date":"2022-10-28T06:40:27","date_gmt":"2022-10-27T22:40:27","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10793"},"modified":"2022-10-28T06:40:27","modified_gmt":"2022-10-27T22:40:27","slug":"zhou-naifu-team-published-research-in-advanced-synthesis-catalysis-in-2022-2075-46-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10793","title":{"rendered":"Zhou, Naifu team published research in Advanced Synthesis &amp; Catalysis  in 2022 | 2075-46-9"},"content":{"rendered":"<p>Pyrazoles and pyrimidines have diverse biological and pharmacological activities.  2075-46-9, formula is C3H3N3O2, Name is  4-Nitro-1H-pyrazole.  There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. <a href=\"https:\/\/www.ambeed.com\/products\/2075-46-9.html\">Recommanded Product: 4-Nitro-1H-pyrazole<\/a>.<\/p>\n<p>Zhou, Naifu;Yu, Jianchao;LiyuanHou;Wu, Xing;Ruan, Zhixiong;Feng, Pengju research published \u300a Electro-oxidative coupling of azoles with 2- and 3-haloindoles\/thiophenes providing access to 2\/3-halo(azol-1-yl)indoles\/thiophenes\u300b, the research content is summarized as follows. This report disclosed an electrochem. oxidative C-H\/N-H cross-coupling method for the synthesis of C-2\/C-3 azolated halo-indoles\/thiophenes such as <strong>I<\/strong> [R = Br, CN, pyrazol-1-yl, etc.; R<sup>1<\/sup> = Br, pyrazol-1-yl, 1,2,4-triazol-1-yl, etc.; R<sup>2<\/sup> = H, Cl, Br, 3-MeC(O)C<sub>6<\/sub>H<sub>4<\/sub>, 4-F<sub>3<\/sub>COC<sub>6<\/sub>H<sub>4<\/sub>; R<sup>3<\/sup> = H, F, Br, CN; X = S, NTs, NSO<sub>2<\/sub>Ph, NC(O)Me]under metal catalyst-free and external chem. oxidant free condition. Hydrogen gas was the only byproduct of this C-H\/N-H cross-coupling reaction. The synthetic utility of this electrochem. approach was highlighted by its easy scalability and compatibility with highly functional indoles and azoles. The retention of halogen on the heterocycles could serve as a useful functional group for future late-stage modifications.<\/p>\n<p><a href=\"https:\/\/www.ambeed.com\/products\/2075-46-9.html\">Recommanded Product: 4-Nitro-1H-pyrazole<\/a>, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g\/mol. The purity is usually 95%.<\/p>\n<p>4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson&#8217;s disease., 2075-46-9.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/2075-46-9.html\">Recommanded Product: 4-Nitro-1H-pyrazole<\/a>, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g\/mol. The purity is usually 95%.<\/p>\n<p>4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson&#8217;s disease., 2075-46-9.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,131],"tags":[732],"class_list":["post-10793","post","type-post","status-publish","format-standard","hentry","category-2075-46-9","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Zhou, Naifu team published research in Advanced Synthesis &amp; Catalysis in 2022 | 2075-46-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazoles and pyrimidines have diverse biological and pharmacological activities. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. 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