{"id":10785,"date":"2022-10-28T06:40:27","date_gmt":"2022-10-27T22:40:27","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10785"},"modified":"2022-10-28T06:40:27","modified_gmt":"2022-10-27T22:40:27","slug":"zhao-ji-ping-team-published-research-in-advanced-synthesis-catalysis-in-2020-2075-46-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10785","title":{"rendered":"Zhao, Ji-Ping team published research in Advanced Synthesis &amp; Catalysis  in 2020 | 2075-46-9"},"content":{"rendered":"<p>Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 2075-46-9, formula is C3H3N3O2, Name is  4-Nitro-1H-pyrazole.  Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. <a href=\"https:\/\/www.ambeed.com\/products\/2075-46-9.html\">Category: pyrazoles-derivatives<\/a>.<\/p>\n<p>Zhao, Ji-Ping;Ding, Lu-jia;Wang, Peng-Cheng;Liu, Ying;Huang, Min-Jun;Zhou, Xin-Li;Lu, Ming research published \u300a Electrochemical Nonacidic N-Nitrosation\/N-Nitration of Secondary Amines through a Biradical Coupling Reaction\u300b, the research content is summarized as follows. An acid-free N-nitrosation\/nitration of the N-H bonds in secondary amines\/azoles with Fe(NO<sub>3<\/sub>)<sub>3<\/sub> \u00b7 9H<sub>2<\/sub>O as the nitroso\/nitro source through an electrocatalyzed radical coupling reaction was developed to give nitroso-amines <strong>I<\/strong> [R = piperidin-1-yl, pyrrolidin-1-yl, morpholin-4-yl, etc.] and nitro-azoles <strong>II<\/strong> [R<sup>1<\/sup> = 3-Me-pyrazol-1-yl, imidazol-1-yl, benzotriazol-1-yl, etc.] under mild conditions. Control and competition experiments, as well as kinetic studies demonstrated that N-nitrosation and N-nitration involved two different radical reaction pathways involving N<sup>+<\/sup> and N<sup>.<\/sup> radicals. Moreover, the electrocatalysis method enabled the preferential activation of the N-H bond over the electrode and thus provided high selectivity for specific N atoms. This strategy exhibited a broad scope and provided a green and straightforward approach to generate useful compounds <strong>I<\/strong> and <strong>II<\/strong> in good yields.<\/p>\n<p>2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g\/mol. The purity is usually 95%.<\/p>\n<p>4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson&#8217;s disease., <a href=\"https:\/\/www.ambeed.com\/products\/2075-46-9.html\">Category: pyrazoles-derivatives<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g\/mol. The purity is usually 95%.<\/p>\n<p>4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson&#8217;s disease., <a href=\"https:\/\/www.ambeed.com\/products\/2075-46-9.html\">Category: pyrazoles-derivatives<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,131],"tags":[732],"class_list":["post-10785","post","type-post","status-publish","format-standard","hentry","category-2075-46-9","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Zhao, Ji-Ping team published research in Advanced Synthesis &amp; Catalysis in 2020 | 2075-46-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. 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