{"id":1071,"date":"2020-11-20T10:28:41","date_gmt":"2020-11-20T02:28:41","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1071"},"modified":"2020-11-20T10:28:41","modified_gmt":"2020-11-20T02:28:41","slug":"the-important-role-of-3-iodo-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1071","title":{"rendered":"The important role of 3-Iodo-1H-pyrazole"},"content":{"rendered":"<p>Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4522-35-4, name is 3-Iodo-1H-pyrazole, A new synthetic method of this compound is introduced below., <a href=\"https:\/\/www.ambeed.com\/products\/4522-35-4.html\">4522-35-4<\/a><\/p>\n<p>Step B: 3-(ter?-Butoxy)-5-(3-iodo-lH-pyrazol-l-yl)pyridazine To a solution of 3-iodopyrazole (0.208 g, 1.072 mmol) in DMF (5.36 mL) was added potassium teri-butoxide (0.132 g, 1.179 mmol) and then stirred at room temperature for 10 min. 3-(t<?r\/-Butoxy)-5-chloropyridazine (0.2 g, 1.072 mmol) was added, then stirred at 100 C for 1 h, and cooled to room temperature. EtOAc and water were added and the organic was washed with water and brine, dried over MgS04, filtered and concentrated. The residue was purified by flash chromatography (ISCO Combiflash, 24 g, 0-30% EtOAc in hexanes) to give 3-(tert-Butoxy)-5-(3-iodo-lH- pyrazol-l-yl)pyridazine, as a white solid. LCMS calc. = 288.95; found = 288.87 (M+H-tert-Bu)+. NMR (500 MHz, CDC13): delta 9.22 (d, J= 2.2 Hz? 1 H); 7.83 (d, J= 2.5 Hz, 1 H); 7.09 (d, J= 2.3 Hz, 1 H); 6.70 (d, J= 2.5 Hz, 1 H); 1.69 (s, 9 H).\n\nThe basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.\n\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147,131],"tags":[126],"class_list":["post-1071","post","type-post","status-publish","format-standard","hentry","category-4522-35-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The important role of 3-Iodo-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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