{"id":1065,"date":"2020-11-19T10:27:01","date_gmt":"2020-11-19T02:27:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1065"},"modified":"2020-11-19T10:27:01","modified_gmt":"2020-11-19T02:27:01","slug":"share-a-compound-ethyl-1h-pyrazole-3-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1065","title":{"rendered":"Share a compound : Ethyl 1H-pyrazole-3-carboxylate"},"content":{"rendered":"

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5932-27-4 name is Ethyl 1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 5932-27-4<\/a><\/p>\n

Step 2: Nitrogen protection, 1H-pyrazole-3-carboxylic acid ethyl ester (3.7 g, 26.2 mmol) dissolved in dry DMF(25 mL), 60percent NaH (1.0 g, 26.2 mmol) was added in four portions at 0 \u00a1\u00e3C. After stirring for 15 min, slowly add 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-fluoropyridine (4.0 g, 20.9 mmol), warmed to 110 \u00a1\u00e3 C and stirred overnight.The reaction was quenched by adding an appropriate amount of water and extracted three times with dichloromethane.The combined organics were dried with MgSO4 for 2 h. Filter out MgSO4,The solvent was distilled off, and the crude product was separated by column chromatography (eluent petroleum ether (60-90 \u00a1\u00e3 C) \/ ethyl acetate, 15:1 by volume) to obtain white powder.Final (5.7 g, yield 88percent).<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[170,131],"tags":[126],"class_list":["post-1065","post","type-post","status-publish","format-standard","hentry","category-5932-27-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : Ethyl 1H-pyrazole-3-carboxylate<\/title>\n<meta name=\"description\" content=\"As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5932-27-4 name is Ethyl 1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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