{"id":1063,"date":"2020-11-19T10:27:01","date_gmt":"2020-11-19T02:27:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1063"},"modified":"2020-11-19T10:27:01","modified_gmt":"2020-11-19T02:27:01","slug":"a-new-synthetic-route-of-3-methylpyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1063","title":{"rendered":"A new synthetic route of 3-Methylpyrazole"},"content":{"rendered":"

1453-58-3<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1453-58-3, name is 3-Methylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

Sodium hydride (30 mg, 1.25 mmol) was added to a solution of 3-methylpyrazole (88 mg, 1.07 mmol) in dry THF (5 cm3) under an atmosphere of argon. A solution of 7-tert-butyl-2-chloro-1-azaxanthone (280 mg, 0.97 mmol) in dry THF (5 cm3) was then added to the reaction mixture, which was stirred at 65 \u00a1\u00e3C for 16 h. The reaction mixture was allowed to cool to room temperature before water (~10 cm3) was added to the reaction mixture. The precipitate was collected via centrifugation and the resultant solid triturated with a minimum volume of Et2O. The solvent was decanted to yield the title compound as a white solid (290 mg, 0.87 mmol, 90percent). deltaH (CDCI3, 400 MHz) 1.39 (9H, s, tBu), 2.37 (1H, s, Me), 6.31 (1H, d, J 2.8, H2′), 7.51 (1H, d, J 8.8, H10), 7.80 (1H, dd, J 8.8; 2.8, H9), 7.99 (1H, d, J 8.4, H2), 8.27 (1H, d, J 2.8, H7), 8.51 (1H, d, J 2.8, H 1′, 8.72 (1H, d, J 8.4, H3). deltac (CDCI3, 100 MHz) 14.2 (Me), 31.6 (C14), 35.1 (C13), 109.7 (C2), 110.1 (C2′), 113.9 (C4), 118.1 (C10), 121.4 (C6), 122.7 (C7), 129.0 (C1′), 133.4 (C9), 140.1 (C3), 148.3 (C8), 153.7 (C11), 153.9 (C12), 154.0 (C3′), 160.0 (C1), 177.0 (C5). m\/z (ES+) 688.9 (100percent, 2M + H), 334.3 (50percent, M + H). HRMS (ES+) 334.1551; C20H20O2N3 requires 334.1550, [M + H]+.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[175,131],"tags":[145],"class_list":["post-1063","post","type-post","status-publish","format-standard","hentry","category-1453-58-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nA new synthetic route of 3-Methylpyrazole<\/title>\n<meta name=\"description\" content=\"1453-58-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1453-58-3, name is 3-Methylpyrazole, This compound has unique chemical properties. 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