{"id":1060,"date":"2020-11-19T10:27:01","date_gmt":"2020-11-19T02:27:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1060"},"modified":"2020-11-19T10:27:01","modified_gmt":"2020-11-19T02:27:01","slug":"share-a-compound-5334-43-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1060","title":{"rendered":"Share a compound : 5334-43-0"},"content":{"rendered":"

5334-43-0<\/a>, Name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, 5334-43-0, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.<\/p>\n

General procedure: To a stirred solution of the intermediate compounds 1a-1d (1 mmol) and triethylamine (2 mmol) in DMF (12 mL) medium, a mixture of EDCI (1 mmol) and HOBt (1mmol) was added and the reaction mixture was stirred at room temperature for 30 min, then a mixture of compounds 2a-2d (1 mmol) and DMF (5 mL) was added, the reaction was stirred at room temperature. And the reaction progress was monitored by TLC. After completion of the reaction, the product was added into chloroform, then extracted from chloroform with water, and washed successively with 0.2 mol\/L hydrochloric acid, water,2 mol\/L sodium hydroxide, water, saturated sodium chloride, then dried, concentrated and purified by preparative thin layer chromatography (PE:EA = 8:1) followed by recrystallization from ethanol.<\/p>\n

Statistics shows that 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 5334-43-0.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 5334-43-0.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[148,131],"tags":[126],"class_list":["post-1060","post","type-post","status-publish","format-standard","hentry","category-5334-43-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 5334-43-0<\/title>\n<meta name=\"description\" content=\"5334-43-0, Name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, 5334-43-0, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1060\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share a compound : 5334-43-0\" \/>\n<meta property=\"og:description\" content=\"5334-43-0, Name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, 5334-43-0, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Share a compound : 5334-43-0","description":"5334-43-0, Name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, 5334-43-0, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=1060","og_locale":"en_US","og_type":"article","og_title":"Share a compound : 5334-43-0","og_description":"5334-43-0, Name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, 5334-43-0, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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