{"id":10597,"date":"2022-10-26T02:54:20","date_gmt":"2022-10-25T18:54:20","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10597"},"modified":"2022-10-26T02:54:20","modified_gmt":"2022-10-25T18:54:20","slug":"chen-bei-et-al-published-their-patent-in-2009-cas-85426-79-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10597","title":{"rendered":"Chen, Bei et al. published their patent in 2009 |CAS: 85426-79-5"},"content":{"rendered":"

On October 15, 2009, Chen, Bei; Jiang, Tao; Marsilje, Thomas H.; Michellys, Pierre-Yves; Nguyen, Truc Ngoc; Pei, Wei; Wu, Baogen; Gao, Zhaobo; Ge, Yonghui; Huang, Chen; Li, Yuncheng published a patent.Computed Properties of 85426-79-5<\/a> The title of the patent was Preparation of pyrimidine derivatives as protein kinase inhibitors for treating proliferative disorders, immune disorders, and infections. And the patent contained the following:<\/p>\n

The invention relates to pyrimidine derivatives having Formula I or II (wherein R1 and R2 are H, C1-6 alkyl or halo-substituted C1-6 alkyl; R3 is halo, C1-6 alkyl, or a halo-substituted C1-6 alkyl; R4 is H; alternatively, R3 and R4 together form part of a ring; R5, R6 and R8 are independently C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl or C2-6 alkynyl, each optionally substituted; R7 is sulfamoyl, carbamoyl, etc.; R9 is -L-S(O)2R18, -L-S(O)2NRR17, etc.; R is H or C1-6alkyl; R17 and R18 are independently C1-6 alkyl, halo-substituted C1-6 alkyl, etc.; L is (CR2)1-4 or a bond; n = 1-2) and methods for using such compounds as kinase inhibitors for disease treatment. For example, the compounds of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, c-ros oncogene (ROS), insulin-like growth factor (IGF-IR), and\/or insulin receptor (InsR) kinase activity or a combination thereof. Synthetic procedures for preparing the pyrimidines of the invention are claimed as are compositions containing them. Example compound III, prepared in a multistep synthesis that culminated in the reaction of corresponding pipieridine intermediate with dimethylamino acetyl halide, had an IC50 of 0.026 \u03bcM in an ALK assay. The experimental process involved the reaction of 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(cas: 85426-79-5).Computed Properties of 85426-79-5<\/a><\/p>\n

The Article related to preparation pyrimidine derivative therapeutic kinase inhibitor, pyrimidine derivative treatment proliferative disorder immune disorder infection, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 85426-79-5<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Article related to preparation pyrimidine derivative therapeutic kinase inhibitor, pyrimidine derivative treatment proliferative disorder immune disorder infection, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 85426-79-5<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[765,131],"tags":[129],"class_list":["post-10597","post","type-post","status-publish","format-standard","hentry","category-85426-79-5","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nChen, Bei et al. published their patent in 2009 |CAS: 85426-79-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On October 15, 2009, Chen, Bei; Jiang, Tao; Marsilje, Thomas H.; Michellys, Pierre-Yves; Nguyen, Truc Ngoc; Pei, Wei; Wu, Baogen; Gao, Zhaobo; Ge, Yonghui; Huang, Chen; Li, Yuncheng published a patent.Computed Properties of 85426-79-5 The title of the patent was Preparation of pyrimidine derivatives as protein kinase inhibitors for treating proliferative disorders, immune disorders, and infections. 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