{"id":10579,"date":"2022-10-26T02:53:05","date_gmt":"2022-10-25T18:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10579"},"modified":"2022-10-26T02:53:05","modified_gmt":"2022-10-25T18:53:05","slug":"walters-w-patrick-et-al-published-their-patent-in-2019-cas-98138-75-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10579","title":{"rendered":"Walters, W. Patrick et al. published their patent in 2019 |CAS: 98138-75-1"},"content":{"rendered":"<p>On August 29, 2019, Walters, W. Patrick; Lescarbeau, Andre; Kelley, Elizabeth H.; Shortsleeves, Kelley C.; Taylor, Alexander M.; Pierce, Levi Charles Thomas; Murcko, Mark Andrew; Giordanetto, Fabrizio; Greisman, Jack Benjamin; Maragakis, Paul; Bhat, Sathesh; Konze, Kyle; Dahlgren, Markus Kristofer; Therrien, Eric published a patent.<a href=\"https:\/\/www.ambeed.com\/products\/98138-75-1.html\">Quality Control of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine<\/a> The title of the patent was Preparation of heterocyclic compounds as SHP2 phosphatase inhibitors. And the patent contained the following:<\/p>\n<p>The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure. Example compound I\u2022formate was prepared by cyclocondensation of tert-Bu (1-(5-amino-1,3,4-thiadiazol-2-yl)-3-methylpiperidin-3-yl)carbamate with 2,3-dichlorobenzaldehyde and 2-isocyano-2,4,4-trimethylpentane followed by deprotection. The invention compounds were evaluated for their SHP2 phosphatase inhibitory activity. From the assay, it was determined that compound I\u2022formate exhibited IC50 value less than 5 \u03bcM. The experimental process involved the reaction of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine(cas: 98138-75-1).<a href=\"https:\/\/www.ambeed.com\/products\/98138-75-1.html\">Quality Control of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine<\/a><\/p>\n<p>The Article related to heterocycle preparation shp2 phosphatase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/98138-75-1.html\">Quality Control of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to heterocycle preparation shp2 phosphatase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/98138-75-1.html\">Quality Control of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[764,131],"tags":[128],"class_list":["post-10579","post","type-post","status-publish","format-standard","hentry","category-98138-75-1","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Walters, W. Patrick et al. published their patent in 2019 |CAS: 98138-75-1 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On August 29, 2019, Walters, W. Patrick; Lescarbeau, Andre; Kelley, Elizabeth H.; Shortsleeves, Kelley C.; Taylor, Alexander M.; Pierce, Levi Charles Thomas; Murcko, Mark Andrew; Giordanetto, Fabrizio; Greisman, Jack Benjamin; Maragakis, Paul; Bhat, Sathesh; Konze, Kyle; Dahlgren, Markus Kristofer; Therrien, Eric published a patent.Quality Control of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine The title of the patent was Preparation of heterocyclic compounds as SHP2 phosphatase inhibitors. And the patent contained the following:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10579\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Walters, W. Patrick et al. published their patent in 2019 |CAS: 98138-75-1 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"On August 29, 2019, Walters, W. Patrick; Lescarbeau, Andre; Kelley, Elizabeth H.; Shortsleeves, Kelley C.; Taylor, Alexander M.; Pierce, Levi Charles Thomas; Murcko, Mark Andrew; Giordanetto, Fabrizio; Greisman, Jack Benjamin; Maragakis, Paul; Bhat, Sathesh; Konze, Kyle; Dahlgren, Markus Kristofer; Therrien, Eric published a patent.Quality Control of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine The title of the patent was Preparation of heterocyclic compounds as SHP2 phosphatase inhibitors. 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Patrick et al. published their patent in 2019 |CAS: 98138-75-1 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-25T18:53:05+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"On August 29, 2019, Walters, W. Patrick; Lescarbeau, Andre; Kelley, Elizabeth H.; Shortsleeves, Kelley C.; Taylor, Alexander M.; Pierce, Levi Charles Thomas; Murcko, Mark Andrew; Giordanetto, Fabrizio; Greisman, Jack Benjamin; Maragakis, Paul; Bhat, Sathesh; Konze, Kyle; Dahlgren, Markus Kristofer; Therrien, Eric published a patent.Quality Control of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine The title of the patent was Preparation of heterocyclic compounds as SHP2 phosphatase inhibitors. 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Patrick et al. published their patent in 2019 |CAS: 98138-75-1 | pyrazoles-derivatives","description":"On August 29, 2019, Walters, W. Patrick; Lescarbeau, Andre; Kelley, Elizabeth H.; Shortsleeves, Kelley C.; Taylor, Alexander M.; Pierce, Levi Charles Thomas; Murcko, Mark Andrew; Giordanetto, Fabrizio; Greisman, Jack Benjamin; Maragakis, Paul; Bhat, Sathesh; Konze, Kyle; Dahlgren, Markus Kristofer; Therrien, Eric published a patent.Quality Control of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine The title of the patent was Preparation of heterocyclic compounds as SHP2 phosphatase inhibitors. And the patent contained the following:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=10579","og_locale":"en_US","og_type":"article","og_title":"Walters, W. 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