{"id":10574,"date":"2022-10-26T02:53:05","date_gmt":"2022-10-25T18:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10574"},"modified":"2022-10-26T02:53:05","modified_gmt":"2022-10-25T18:53:05","slug":"perma-tenzin-puno-et-al-published-their-patent-in-2022-cas-1014631-89-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10574","title":{"rendered":"Perma Tenzin, Puno et al. published their patent in 2022 |CAS: 1014631-89-0"},"content":{"rendered":"<p>On July 29, 2022, Perma Tenzin, Puno; Sun, Handong; Zhou, Yuanfei; Yan, Bingchao; Yang, Qian; Du, Xue; Hu, Kun published a patent.<a href=\"https:\/\/www.ambeed.com\/products\/1014631-89-0.html\">Related Products of 1014631-89-0<\/a> The title of the patent was Preparation of ent-kauranoid derivatives as antitumor drugs. And the patent contained the following:<\/p>\n<p>The invention discloses a preparation of ent-kauranoid derivatives I [wherein R=(un)substituted C3-C8 alkyl and cycloalkyl, heterocyclic group containing N, O, S, substituted Ph, etc.] as antitumor drugs, which has the advantages of easy availability of raw materials, high yield and good anti-tumor effect. For example, (3aS,5aR,6S,7aR,10S,12aS,12bR,13R)-6-hydroxy-5,5-dimethyl-9-methylene-3,7,8-trioxododecahydro-1H,3H-7a,10-methanocyclohepta[6,7]indeno[1,7a-c]furan-13-yl butyrate was prepared by the following steps: oxidation of oridonin; selective reduction; diazotization; oxidation; rearrangement reaction; cyclization to obtain calyx lactone B; esterification. The title compound is used to prepare anti-tumor drugs, and tumors include cervical cancer, colon cancer, ovarian cancer, lung cancer, prostate cancer, breast cancer and liver cancer. The experimental process involved the reaction of 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylic acid(cas: 1014631-89-0).<a href=\"https:\/\/www.ambeed.com\/products\/1014631-89-0.html\">Related Products of 1014631-89-0<\/a><\/p>\n<p>The Article related to preparation ent kauranoid antitumor oxidation reduction diazotization cyclization esterification, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/1014631-89-0.html\">Related Products of 1014631-89-0<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to preparation ent kauranoid antitumor oxidation reduction diazotization cyclization esterification, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/1014631-89-0.html\">Related Products of 1014631-89-0<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[768,131],"tags":[128],"class_list":["post-10574","post","type-post","status-publish","format-standard","hentry","category-1014631-89-0","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Perma Tenzin, Puno et al. published their patent in 2022 |CAS: 1014631-89-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On July 29, 2022, Perma Tenzin, Puno; Sun, Handong; Zhou, Yuanfei; Yan, Bingchao; Yang, Qian; Du, Xue; Hu, Kun published a patent.Related Products of 1014631-89-0 The title of the patent was Preparation of ent-kauranoid derivatives as antitumor drugs. 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