{"id":1057,"date":"2020-11-18T10:35:42","date_gmt":"2020-11-18T02:35:42","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1057"},"modified":"2020-11-18T10:35:42","modified_gmt":"2020-11-18T02:35:42","slug":"new-downstream-synthetic-route-of-5744-51-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1057","title":{"rendered":"New downstream synthetic route of 5744-51-4"},"content":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 5744-51-4, name is Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life. 5744-51-4<\/a><\/p>\n

LAH (1.05 M in THF, 15.0 kg, 17.4 mol) was gradually added to a stirring solution of ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate (5.33 kg, 31 .7 mol) in THF (10.7 L) over 1.5 h at 4- 23 C, followed by THF (1.0 L). After 30 min, the solution was cooled to 15 C, then, while continuing to cool, a solution of water (0.66 L, 37 mol) in THF (1.9 L) was gradually added over 20 min. Aq. NaOH (15 wt%, 0.66 L, 2.8 mol) was then added over a few min, followed by water (2.0 L). The resulting slurry was stirred for 20 min at 4-1 1 C then filtered under suction. The collected solids were washed four times with THF (10.7 L per wash) to give (1 ,5-dimethyl-1 H- pyrazol-3-yl)methanol as a solution in the collected filtrates. (0239<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 5744-51-4. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 5744-51-4. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[198,131],"tags":[126],"class_list":["post-1057","post","type-post","status-publish","format-standard","hentry","category-5744-51-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of 5744-51-4<\/title>\n<meta name=\"description\" content=\"The chemical industry reduces the impact on the environment during synthesis 5744-51-4, name is Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life. 5744-51-4\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1057\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New downstream synthetic route of 5744-51-4\" \/>\n<meta property=\"og:description\" content=\"The chemical industry reduces the impact on the environment during synthesis 5744-51-4, name is Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life. 5744-51-4\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1057\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-18T02:35:42+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1057\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1057\",\"name\":\"New downstream synthetic route of 5744-51-4\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-11-18T02:35:42+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"The chemical industry reduces the impact on the environment during synthesis 5744-51-4, name is Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life. 5744-51-4\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1057#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1057\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1057#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New downstream synthetic route of 5744-51-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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