{"id":10563,"date":"2022-10-26T02:53:05","date_gmt":"2022-10-25T18:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10563"},"modified":"2022-10-26T02:53:05","modified_gmt":"2022-10-25T18:53:05","slug":"chen-wei-et-al-published-their-patent-in-2016-cas-924909-16-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10563","title":{"rendered":"Chen, Wei et al. published their patent in 2016 |CAS: 924909-16-0"},"content":{"rendered":"

On January 7, 2016, Chen, Wei; Wang, Longcheng; Yan, Shunqi; Loury, David J.; Jia, Zhaozhong J.; Frye, Leah Lynn; Greenwood, Jeremy Robert; Shelley, Mee Yoo; Atallah, Gordana Babic; Zanaletti, Riccardo; Catalani, Maria Pia; Raveglia, Luca Francesco published a patent.Recommanded Product: 924909-16-0<\/a> The title of the patent was Preparation of substituted pyrazolopyridines as inhibitors of Bruton’s tyrosine kinase. And the patent contained the following:<\/p>\n

The title compounds I [one of W1 and W2 = C(R9), or N; and the other C(R9); Z = C(R9) or N; L1 = N(R5), O, S or alkyl; T1 = O, N(R5), S, alkylene, or a single bond; Cy1 = substituted aryl or heteroaryl; Cy2 = (un)substituted heterocycloalkyl, aryl, cycloalkyl, or heteroaryl; R1 = H, halo, alkyl, etc; R5 = H, alkyl, heteroalkyl; or when each of L1 and T1 = (independently) N(R5), then the two R5 may join together to form (un)substituted heterocycle; each R9 = (independently) H, halo, CN, etc.] that inhibit Bruton’s tyrosine kinase (Btk), were prepared and formulated. E.g., a multi-step synthesis of 3-hydrazinylpropanenitrile, was described. The Btk IC50 of compounds I was determined in both a cellular kinase assay and in a cellular functional assay of BCR-induced calcium flux (data given). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds I. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. The experimental process involved the reaction of 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol(cas: 924909-16-0).Recommanded Product: 924909-16-0<\/a><\/p>\n

The Article related to pyrazolopyridine preparation bruton’s tyrosine kinase btk inhibitor antitumor antiinflammatory, lymphoma autoimmune heteroimmune disease treatment pyrazolopyridine preparation btk inhibitor and other aspects.Recommanded Product: 924909-16-0<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Article related to pyrazolopyridine preparation bruton’s tyrosine kinase btk inhibitor antitumor antiinflammatory, lymphoma autoimmune heteroimmune disease treatment pyrazolopyridine preparation btk inhibitor and other aspects.Recommanded Product: 924909-16-0<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[767,131],"tags":[129],"class_list":["post-10563","post","type-post","status-publish","format-standard","hentry","category-924909-16-0","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nChen, Wei et al. published their patent in 2016 |CAS: 924909-16-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On January 7, 2016, Chen, Wei; Wang, Longcheng; Yan, Shunqi; Loury, David J.; Jia, Zhaozhong J.; Frye, Leah Lynn; Greenwood, Jeremy Robert; Shelley, Mee Yoo; Atallah, Gordana Babic; Zanaletti, Riccardo; Catalani, Maria Pia; Raveglia, Luca Francesco published a patent.Recommanded Product: 924909-16-0 The title of the patent was Preparation of substituted pyrazolopyridines as inhibitors of Bruton's tyrosine kinase. 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