{"id":10557,"date":"2022-10-26T02:51:49","date_gmt":"2022-10-25T18:51:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10557"},"modified":"2022-10-26T02:51:49","modified_gmt":"2022-10-25T18:51:49","slug":"demeese-jason-et-al-published-their-patent-in-2009-cas-924909-16-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10557","title":{"rendered":"Demeese, Jason et al. published their patent in 2009 |CAS: 924909-16-0"},"content":{"rendered":"<p>On March 12, 2009, Demeese, Jason; Gaudino, John; Neitzel, Alicia Tarin; Lunghofer, Paul; Jeongbeob, Seo; Hongqi, Tian; Young, Wendy B.; Sutherlin, Daniel P. published a patent.<a href=\"https:\/\/www.ambeed.com\/products\/924909-16-0.html\">HPLC of Formula: 924909-16-0<\/a> The title of the patent was Preparation of pyrazolopyridines as tyrosine kinase inhibitors. And the patent contained the following:<\/p>\n<p>Title compounds[I, II; X = O, S, NR10; W = O, S, SO, SO2; R1 = H, alkyl, alkenyl, alkynyl, CONR10R11, (substituted) carbocyclyl, heterocyclyl, aryl, heteroaryl, etc.; R2 = H, CF3, cyano, NR10R11, (substituted) alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, etc.; R3 = (substituted) carbocyclyl, heterocyclyl, aryl, heteroaryl; R4 = H, F, Cl, Br, CF3, cyano, NR10R11, OR10, etc.; R10, R11 = H, (substituted) alkyl, alkenyl, alkynyl, carbocyclyl, heteroaryl, etc.], were prepared as c-MET kinase inhibitors (no data). Thus, title compound (III) was prepared in 13 steps from 2,2-dimethyl-1,3-dioxane-4,6-dione, 1-(4-methoxybenzyl)-1H-pyrazol-5-amine, 1,2-difluoro-4-nitrobenzene, 1-(4-fluorophenyl)hydrazine hydrochloride, 1,3-dioxane-4,6-dione, and tert-Bu 4-hydroxypiperidine-1-carboxylate. The experimental process involved the reaction of 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol(cas: 924909-16-0).<a href=\"https:\/\/www.ambeed.com\/products\/924909-16-0.html\">HPLC of Formula: 924909-16-0<\/a><\/p>\n<p>The Article related to pyrazolopyridine preparation tyrosine kinase inhibitor, cmet kinase inhibitor piperidinyloxypyrazolopyridine preparation, cancer stroke diabetes hepatomegaly alzheimers treatment phenoxypyrazolopyridine preparation and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/924909-16-0.html\">HPLC of Formula: 924909-16-0<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to pyrazolopyridine preparation tyrosine kinase inhibitor, cmet kinase inhibitor piperidinyloxypyrazolopyridine preparation, cancer stroke diabetes hepatomegaly alzheimers treatment phenoxypyrazolopyridine preparation and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/924909-16-0.html\">HPLC of Formula: 924909-16-0<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[767,131],"tags":[129],"class_list":["post-10557","post","type-post","status-publish","format-standard","hentry","category-924909-16-0","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Demeese, Jason et al. published their patent in 2009 |CAS: 924909-16-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On March 12, 2009, Demeese, Jason; Gaudino, John; Neitzel, Alicia Tarin; Lunghofer, Paul; Jeongbeob, Seo; Hongqi, Tian; Young, Wendy B.; Sutherlin, Daniel P. published a patent.HPLC of Formula: 924909-16-0 The title of the patent was Preparation of pyrazolopyridines as tyrosine kinase inhibitors. 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