{"id":10555,"date":"2022-10-26T02:51:49","date_gmt":"2022-10-25T18:51:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10555"},"modified":"2022-10-26T02:51:49","modified_gmt":"2022-10-25T18:51:49","slug":"lancellotti-patrizio-et-al-published-their-patent-in-2021-cas-85426-79-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10555","title":{"rendered":"Lancellotti, Patrizio et al. published their patent in 2021 |CAS: 85426-79-5"},"content":{"rendered":"<p>On September 23, 2021, Lancellotti, Patrizio; Oury, Cecile; Pirotte, Bernard; Musumeci, Lucia; Jacques, Nicolas; Goffin, Eric published a patent.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Product Details of 85426-79-5<\/a> The title of the patent was Preparation of pyrimidine derivatives for prevention and treatment of Gram-negative bacterial infection, contamination and fouling. And the patent contained the following:<\/p>\n<p>This invention relates to new pyrimidine derivatives I [X1 and X2 = (independently) N, (un)substituted CH (with the exception that if one of X1 or X2 is N, then the remaining of X1 or X2 = (un)substituted CH); Y = O or S; R1 and R2 = (independently) alkyl, cycloalkyl, aryl, etc.; R3-R7 = (independently) H, halo, alkyl, etc.] or pharmaceutically acceptable acid addition salts, together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-neg. bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-neg. biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. E.g., a multi-step synthesis of (1R,2S)-II, starting from 4,6-dichloro-2-(propylthio)pyrimidin-5-amine and methylamine, was disclosed. Antibacterial effects of representative compounds I together with Polymyxin B Nonapeptide (membrane penetrating agent) on Escherichia coli were examined (data given). A method of diagnosing or prognosing a Gram-neg. bacterial infection in a host mammal comprising using the pyrimidine derivatives I together with a membrane penetrating agent, was disclosed. The experimental process involved the reaction of 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(cas: 85426-79-5).<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Product Details of 85426-79-5<\/a><\/p>\n<p>The Article related to pyrimidine derivative pyrrolopyrimidinamine phenylcyclopropyl preparation gram neg bacterial infection, antibacterial combination chemotherapy membrane penetrating agent pyrrolopyrimidinamine phenylcyclopropyl preparation and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Product Details of 85426-79-5<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to pyrimidine derivative pyrrolopyrimidinamine phenylcyclopropyl preparation gram neg bacterial infection, antibacterial combination chemotherapy membrane penetrating agent pyrrolopyrimidinamine phenylcyclopropyl preparation and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Product Details of 85426-79-5<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[765,131],"tags":[129],"class_list":["post-10555","post","type-post","status-publish","format-standard","hentry","category-85426-79-5","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lancellotti, Patrizio et al. published their patent in 2021 |CAS: 85426-79-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On September 23, 2021, Lancellotti, Patrizio; Oury, Cecile; Pirotte, Bernard; Musumeci, Lucia; Jacques, Nicolas; Goffin, Eric published a patent.Product Details of 85426-79-5 The title of the patent was Preparation of pyrimidine derivatives for prevention and treatment of Gram-negative bacterial infection, contamination and fouling. 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