{"id":10554,"date":"2022-10-26T02:51:49","date_gmt":"2022-10-25T18:51:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10554"},"modified":"2022-10-26T02:51:49","modified_gmt":"2022-10-25T18:51:49","slug":"seela-frank-et-al-published-their-research-in-nucleosides-nucleotides-nucleic-acids-in-2005-cas-85426-79-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10554","title":{"rendered":"Seela, Frank et al. published their research in Nucleosides, Nucleotides &#038; Nucleic Acids in 2005 |CAS: 85426-79-5"},"content":{"rendered":"<p>Seela, Frank; Jawalekar, Anup M.; Sun, Lijuan; Leonard, Peter published an article in 2005, the title of the article was Oligonucleotides Containing Pyrazolo[3,4-d]Pyrimidines: 8-Aza-7-deazaadenines With Bulky Substituents in the 2- or 7-Position.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Product Details of 85426-79-5<\/a> And the article contains the following content:<\/p>\n<p>The synthesis of the 2&#8242;-deoxyadenosine analogs, e.g. I, modified at the 7- and\/or 2-position is described. The effect of 7-chloro and 2-methylthio groups on the duplex stability is evaluated. For that, the nucleosides, e.g. I, were converted to the corresponding phosphoramidites, which were employed in the solid-phase oligonucleotide synthesis. In oligonucleotide duplexes, compound I forms stable base pairs with dT, of which the separated I-dT base pairs contribute stronger than that of the consecutive base pairs. Nucleoside II shows universal base pairing properties while its N8 isomer forms duplexes with lower stability. The experimental process involved the reaction of 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(cas: 85426-79-5).<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Product Details of 85426-79-5<\/a><\/p>\n<p>The Article related to structure property thermodn thermal stability dna duplex synthesis, dna duplex synthesis thermal stability thermodn, oligonucleotide pyrazolopyrimidine azadeazaadenine synthesis dna duplex stability nucleoside phosphoramidite and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Product Details of 85426-79-5<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to structure property thermodn thermal stability dna duplex synthesis, dna duplex synthesis thermal stability thermodn, oligonucleotide pyrazolopyrimidine azadeazaadenine synthesis dna duplex stability nucleoside phosphoramidite and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/85426-79-5.html\">Product Details of 85426-79-5<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[765,131],"tags":[129],"class_list":["post-10554","post","type-post","status-publish","format-standard","hentry","category-85426-79-5","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Seela, Frank et al. published their research in Nucleosides, Nucleotides &amp; 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Sun, Lijuan; Leonard, Peter published an article in 2005, the title of the article was Oligonucleotides Containing Pyrazolo[3,4-d]Pyrimidines: 8-Aza-7-deazaadenines With Bulky Substituents in the 2- or 7-Position.Product Details of 85426-79-5 And the article contains the following content:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10554\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-25T18:51:49+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10554\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10554\",\"name\":\"Seela, Frank et al. published their research in Nucleosides, Nucleotides & Nucleic Acids in 2005 |CAS: 85426-79-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-25T18:51:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Seela, Frank; Jawalekar, Anup M.; Sun, Lijuan; Leonard, Peter published an article in 2005, the title of the article was Oligonucleotides Containing Pyrazolo[3,4-d]Pyrimidines: 8-Aza-7-deazaadenines With Bulky Substituents in the 2- or 7-Position.Product Details of 85426-79-5 And the article contains the following content:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10554#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10554\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10554#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Seela, Frank et al. published their research in Nucleosides, Nucleotides &#038; Nucleic Acids in 2005 |CAS: 85426-79-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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