{"id":10552,"date":"2022-10-26T02:51:49","date_gmt":"2022-10-25T18:51:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10552"},"modified":"2022-10-26T02:51:49","modified_gmt":"2022-10-25T18:51:49","slug":"rajashakar-v-et-al-published-their-research-in-pharma-chemica-in-2016-cas-36640-53-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10552","title":{"rendered":"Rajashakar, V. et al. published their research in Pharma Chemica in 2016 |CAS: 36640-53-6"},"content":{"rendered":"<p>Rajashakar, V.; Saisree, K.; Sikender, M.; Naveen, S.; Madhava Reddy, B.; Harinadha Babu, V. published an article in 2016, the title of the article was Synthesis of pyrazolyl thiobarbituric acids and their cytotoxic and antimicrobial evaluation.<a href=\"https:\/\/www.ambeed.com\/products\/36640-53-6.html\">HPLC of Formula: 36640-53-6<\/a> And the article contains the following content:<\/p>\n<p>Synthesis, cytotoxic and anti-microbial screening of novel thiobarbituric acid incorporated pyrazole derivatives I [Ar = Ph, 4-H3CC6H4, 4-HOC6H4, 4-ClC6H4 and 2-naphthyl] were performed. Vilsmeier-Haack reaction of different Ph hydrazones afforded pyrazole-4-carbaldehydes in good yields. Knoevenagel condensation of compounds with thiobarbituric acid gave a series of 5-ylidene derivatives I in reasonable yields. The synthesized compounds were characterized with the help of IR, 1H-NMR and mass spectral data. The compounds were tested for cytotoxic activity against Vero, MCF-7 and HCT-116 cell lines. Among the tested compounds, compound I [Ar = 4-HOC6H4] was found to be most active mol. with the activity against both MCF-7 and HCT-116 cell lines with IC50 values of 14.0 \u03bcM and 18.12 \u03bcM. In anti-microbial screening, none of the compounds exhibited anti-bacterial activity. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).<a href=\"https:\/\/www.ambeed.com\/products\/36640-53-6.html\">HPLC of Formula: 36640-53-6<\/a><\/p>\n<p>The Article related to arylethylideneamino aniline preparation vilsmeir haack reaction, aryl phenylpyrazolyl carboxaldehyde preparation thiobarbituric acid knoevenagel condensation, phenyl arylpyrazolylmethylene thioxopyrimidine dione preparation antibacterial antitumor activity sar and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/36640-53-6.html\">HPLC of Formula: 36640-53-6<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Article related to arylethylideneamino aniline preparation vilsmeir haack reaction, aryl phenylpyrazolyl carboxaldehyde preparation thiobarbituric acid knoevenagel condensation, phenyl arylpyrazolylmethylene thioxopyrimidine dione preparation antibacterial antitumor activity sar and other aspects.<a href=\"https:\/\/www.ambeed.com\/products\/36640-53-6.html\">HPLC of Formula: 36640-53-6<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[762,131],"tags":[129],"class_list":["post-10552","post","type-post","status-publish","format-standard","hentry","category-36640-53-6","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Rajashakar, V. et al. published their research in Pharma Chemica in 2016 |CAS: 36640-53-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Rajashakar, V.; Saisree, K.; Sikender, M.; Naveen, S.; Madhava Reddy, B.; Harinadha Babu, V. published an article in 2016, the title of the article was Synthesis of pyrazolyl thiobarbituric acids and their cytotoxic and antimicrobial evaluation.HPLC of Formula: 36640-53-6 And the article contains the following content:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10552\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rajashakar, V. et al. published their research in Pharma Chemica in 2016 |CAS: 36640-53-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Rajashakar, V.; Saisree, K.; Sikender, M.; Naveen, S.; Madhava Reddy, B.; Harinadha Babu, V. published an article in 2016, the title of the article was Synthesis of pyrazolyl thiobarbituric acids and their cytotoxic and antimicrobial evaluation.HPLC of Formula: 36640-53-6 And the article contains the following content:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10552\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-25T18:51:49+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10552\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10552\",\"name\":\"Rajashakar, V. et al. published their research in Pharma Chemica in 2016 |CAS: 36640-53-6 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-25T18:51:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Rajashakar, V.; 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