{"id":10546,"date":"2022-10-26T02:51:49","date_gmt":"2022-10-25T18:51:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10546"},"modified":"2022-10-26T02:51:49","modified_gmt":"2022-10-25T18:51:49","slug":"ashok-dongamanti-et-al-published-their-research-in-medicinal-chemistry-research-in-2016-cas-36640-53-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10546","title":{"rendered":"Ashok, Dongamanti et al. published their research in Medicinal Chemistry Research in 2016 |CAS: 36640-53-6"},"content":{"rendered":"

On March 31, 2016, Ashok, Dongamanti; Rangu, Kavitha; Hanumantha Rao, Velagapuri; Gundu, Srinivas; Srilata, Ballu; Vijjulatha, Manga published an article.COA of Formula: C20H14N2O<\/a> The title of the article was Microwave-assisted synthesis, molecular docking and antimicrobial activity of novel 2-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-8H-pyrano[2,3-f]chromen-4-ones. And the article contained the following:<\/p>\n

A series of pyrano[2,3-f]chromenones I [Ar = C6H5, 4-BrC6H4, 3,4-(MeO)2C6H3, 2-naphthyl, etc.] was synthesized via microwave-assisted cyclization of chalcones II in the presence of iodine in DMSO. Precursor chalcones II were prepared by Claisen-Schmidt condensation of 1-(5-hydroxy-2H-chromen-6-yl)ethanone and substituted pyrazole aldehydes using KOH under microwave irradiation This approach for the preparation of pyrano[2,3-f]chromenones I offers the advantages of short reaction time (3-5 min), mild reaction conditions and high yields of products. The newly synthesized compounds I and II were tested in vitro for their antibacterial and antifungal activities. Among the tested compounds, compounds I [Ar = 4-ClC6H4, 4-HOC6H4, 3,4-(MeO)2C6H3] and II [Ar = 3-EtOC6H4] were found to be potent against tested bacterial strains whereas compounds I [Ar = 4-ClC6H4, 3,4-(MeO)2C6H3] and II [Ar = 4-EtOC6H4] were found to be potent against tested fungal strains. Furthermore, the synthesized compounds were subjected to mol. docking studies for the inhibition of enzyme DNA gyrase and compounds I [Ar = 4-HOC6H4, 4-EtOC6H4] showed promising dock score values. The in silico mol. docking results of compounds I and II were in accordance with the in vitro antimicrobial studies and they may be considered as good inhibitor of DNA gyrase. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).COA of Formula: C20H14N2O<\/a><\/p>\n

The Article related to pyranochromenone pyrazolyl preparation antibacterial antifungal mol docking, hydroxychromenyl pyrazolyl propenone preparation oxidative cyclization microwave irradiation, pyrazole aldehyde hydroxychromenyl ethanone claisen schmidt condensation microwave irradiation, pyrazolyl hydroxychromenyl propenone antibacterial antifungal mol docking and other aspects.COA of Formula: C20H14N2O<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The Article related to pyranochromenone pyrazolyl preparation antibacterial antifungal mol docking, hydroxychromenyl pyrazolyl propenone preparation oxidative cyclization microwave irradiation, pyrazole aldehyde hydroxychromenyl ethanone claisen schmidt condensation microwave irradiation, pyrazolyl hydroxychromenyl propenone antibacterial antifungal mol docking and other aspects.COA of Formula: C20H14N2O<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[762,131],"tags":[129],"class_list":["post-10546","post","type-post","status-publish","format-standard","hentry","category-36640-53-6","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nAshok, Dongamanti et al. published their research in Medicinal Chemistry Research in 2016 |CAS: 36640-53-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"On March 31, 2016, Ashok, Dongamanti; Rangu, Kavitha; Hanumantha Rao, Velagapuri; Gundu, Srinivas; Srilata, Ballu; Vijjulatha, Manga published an article.COA of Formula: C20H14N2O The title of the article was Microwave-assisted synthesis, molecular docking and antimicrobial activity of novel 2-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-8H-pyrano[2,3-f]chromen-4-ones. 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