{"id":1051,"date":"2020-11-18T10:35:42","date_gmt":"2020-11-18T02:35:42","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1051"},"modified":"2020-11-18T10:35:42","modified_gmt":"2020-11-18T02:35:42","slug":"simple-exploration-of-26621-44-3-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1051","title":{"rendered":"Simple exploration of 26621-44-3"},"content":{"rendered":"

26621-44-3<\/a>, Name is 3-Nitro-1H-pyrazole, 26621-44-3, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.<\/p>\n

Into a 250-mL round-bottom flask was placed a solution of 3-nitro-lH-pyrazole (10 g, 88.4 mmol) in DMF (100 mL). This was followed by the addition of NaH (60% wt, 3.9 g, 97.5 mmol) in portions at 0C. The resulting solution was stirred for 0.5 h at 0C. This was followed by the addition of 2-bromopropane (14.1 g, 114.6 mmol) dropwise with stirring at 0C in 10 min. The resulting solution was stirred for 16 h at RT and then was quenched by the addition of 100 mL of water. The resulting solution was extracted with 3×100 mL of ethyl acetate. The organic layers were combined and dried over anhydrous Na2S04, then concentrated under vacuum. The residue was applied onto a silica gel column and eluted with a gradient of ethyl acetate\/petroleum ether (1 :5 to 1 :3). This resulted in 11.8 g (86%) of the title compound as yellow oil. MS-ESI: 156.1 (M+l).<\/p>\n

Statistics shows that 3-Nitro-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 26621-44-3.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 3-Nitro-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 26621-44-3.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[163,131],"tags":[126],"class_list":["post-1051","post","type-post","status-publish","format-standard","hentry","category-26621-44-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of 26621-44-3<\/title>\n<meta name=\"description\" content=\"26621-44-3, Name is 3-Nitro-1H-pyrazole, 26621-44-3, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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