{"id":10504,"date":"2022-10-21T07:00:22","date_gmt":"2022-10-20T23:00:22","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10504"},"modified":"2022-10-21T07:00:22","modified_gmt":"2022-10-20T23:00:22","slug":"taldone-tonys-team-published-research-in-heterocycles-in-2013-cas-847818-74-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10504","title":{"rendered":"Taldone, Tony’s team published research in Heterocycles in 2013 | CAS: 847818-74-0"},"content":{"rendered":"

Product Details of 847818-74-0<\/a>In 2013 ,\u300aPreparation of a diverse purine-scaffold library via one-step palladium catalyzed cross-coupling\u300b appeared in Heterocycles. The author of the article were Taldone, Tony; Zatorska, Danuta; Patel, Hardik J.; Sun, Weilin; Patel, Maulik R.; Chiosis, Gabriela. The article conveys some information:<\/p>\n

In an ongoing efforts to prepare Hsp90 inhibitors (heat-shock proteins HSP 90 inhibitors), various cross-coupling reactions (Suzuki, Stille, Heck, and Sonogashira) were used to construct a diverse library of substituted purines in a single step from PU-H71. The authors showed show that these reactions, particularly a Suzuki coupling, are highly efficient, do not require protection of the pendant amine and due to a wide variety of com. available substrates, allow for the rapid development of a diverse purine library. The products derived from these reactions will permit the exploration of the chem. space occupied by the key 6′-iodine of PU-H71 through mols. with diverse phys. and chem. properties with the potential to be useful for diseases in which Hsp90 is implicated. The synthesis of the target compounds was achieved using 6-amino-8-[(6-iodo-1,3-benzodioxolyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine as a key starting material in a reaction with boronic acid derivatives., alkenes, alkynes and organotin compounds (stannane compounds). The title compounds thus formed included 6-amino-N-(1-methylethyl)-8-[[6-(2-oxazolyl)-1,3-benzodioxolyl]thio]-9H-purine-9-propanamine (I) and related substances, such as derivatives of pyrimidine, pyrazine, imidazole, thiazole, alkenes, isoxazole, pyrazole , furan, pyrrole, pyridine, cyclohexane, cyclopentane, alkyne derivatives In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Product Details of 847818-74-0<\/a>)<\/p>\n

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Product Details of 847818-74-0<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Product Details of 847818-74-0<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[744,131],"tags":[129],"class_list":["post-10504","post","type-post","status-publish","format-standard","hentry","category-847818-74-0","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nTaldone, Tony's team published research in Heterocycles in 2013 | CAS: 847818-74-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Product Details of 847818-74-0In 2013 ,\u300aPreparation of a diverse purine-scaffold library via one-step palladium catalyzed cross-coupling\u300b appeared in Heterocycles. The author of the article were Taldone, Tony; Zatorska, Danuta; Patel, Hardik J.; Sun, Weilin; Patel, Maulik R.; Chiosis, Gabriela. 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