{"id":10489,"date":"2022-10-21T06:59:36","date_gmt":"2022-10-20T22:59:36","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10489"},"modified":"2022-10-21T06:59:36","modified_gmt":"2022-10-20T22:59:36","slug":"chen-changles-team-published-research-in-organometallics-in-2010-cas-20154-03-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10489","title":{"rendered":"Chen, Changle&#8217;s team published research in Organometallics in 2010 | CAS: 20154-03-4"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">HPLC of Formula: 20154-03-4<\/a>In 2010 ,\u300aLewis Acid Catalyzed Synthesis of Poly(pyrazolyl)borate Ligands\u300b appeared in Organometallics. The author of the article were Chen, Changle; Jordan, Richard F.. The article conveys some information:<\/p>\n<p>Lewis acids catalyze the reaction of Li[MeBH3] and Na[BH4] with pyrazoles to yield poly(pyrazolyl)borates under mild conditions. The reaction of Li[MeBH3] with 2 equiv of 3-mesitylpyrazole (HpzMs) at 23\u00b0 (2 days) affords Li[MeB(3-mesityl-pz)2H] (Li[MeBpMs]) and Li[MeB(3-mesityl-pz)(5-mesityl-pz)H] (Li[MeBpMs*]) in 88% yield (3:1 isomer ratio) in the presence of MeB(OiPr)2 (5 mol % vs. HpzMs) but only 28% yield without this additive. Similar enhancements in the yield of Li[MeBpR] products are observed in the reaction of Li[MeBH3] with 3-tBu-pyrazole, 3,5-Me2-pyrazole (Hpz*), and 3,5-tBu2-pyrazole. The kinetics of the MeB(OiPr)2-catalyzed and uncatalyzed reaction of Li[MeB(3-mesityl-pz)H2]\/Li[MeB(5-mesityl-pz)H2] with HpzMs were compared assuming that Li[MeB(3-mesityl-pz)H2] and Li[MeB(5-mesityl-pz)H2] react at the same rate. The estimated second-order rate constants are k(catalyzed) = 1.0 \u00d7 10-4 M-1 s-1 and k(uncatalyzed) = 2.1 \u00d7 10-5 M-1 s-1 at 23\u00b0 in THF. The reaction of Li[MeBH3] with 3 equiv of HpzMs (THF, 60\u00b0, 2 days) in the presence of 3 mol % MeB(OiPr)2 affords Li[MeB(3-mesityl-pz)3] (75% yield), but only Li[MeBpMs] and Li[MeBpMs*] without this additive. Similar results were observed for the reaction of Li[MeBH3] with 3-CF3-pyrazole. The reaction of Na[BH4] and 3 equiv of Hpz* (THF, 60\u00b0, 4 h) gave Na[B(3,5-Me2-pz)2H2] in 93% yield in the presence of BF3\u00b7Et2O (5 mol % vs. Hpz*) but only 5% without this additive. Coordination of the pyrazole to the Lewis acid is expected to decrease the pKa of the pyrazole and increase the rate of B-H bond protonolysis. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">HPLC of Formula: 20154-03-4<\/a>)<\/p>\n<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">HPLC of Formula: 20154-03-4<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">HPLC of Formula: 20154-03-4<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[128],"class_list":["post-10489","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Chen, Changle&#039;s team published research in Organometallics in 2010 | CAS: 20154-03-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"HPLC of Formula: 20154-03-4In 2010 ,\u300aLewis Acid Catalyzed Synthesis of Poly(pyrazolyl)borate Ligands\u300b appeared in Organometallics. 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