{"id":10475,"date":"2022-10-21T06:58:52","date_gmt":"2022-10-20T22:58:52","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10475"},"modified":"2022-10-21T06:58:52","modified_gmt":"2022-10-20T22:58:52","slug":"moraes-paulo-a-s-team-published-research-in-chemistryselect-in-2020-cas-20154-03-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10475","title":{"rendered":"Moraes, Paulo A.&#8217;s team published research in ChemistrySelect in 2020 | CAS: 20154-03-4"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Formula: C4H3F3N2<\/a>In 2020 ,\u300aPyrazole-Enaminones as Promising Prototypes for the Development of Analgesic Drugs\u300b appeared in ChemistrySelect. The author of the article were Moraes, Paulo A.; Brum, Evelyne S.; Brusco, Indiara; Marangoni, Mario A.; Lobo, Marcio M.; Camargo, Adriano F.; Nogara, Pablo A.; Bonacorso, Helio G.; Martins, Marcos A. P.; Da Rocha, Joao Batista T.; Oliveira, Sara M.; Zanatta, Nilo. The article conveys some information:<\/p>\n<p>This study reports the chemo- and regioselective synthesis, at good yields, of (E)-4-(amino)-1,1,1-trifluoro-5-(4,5-alkyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pent-3-en-2-ones (pyrazole-enaminones), from the of N-alkylation reaction of trifluoromethyl pyrazoles with 5-bromo enaminones. The obtained compounds were tested as potential analgesics in a screening test involving mice. Three of these compounds significantly reduced the spontaneous nociception induced by the application of capsaicin, which is an algogenic substance. Compound I presented satisfactory antinociceptive activity compared to celecoxib, a drug used as a pos. control, without promoting locomotor changes in the mice. Moreover, mol. modeling simulations showed that compound I interacts with the cyclooxygenase enzyme at the same binding site as celecoxib. Together, present data suggest that compound I is a promising prototype for the development of new analgesic drugs. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Formula: C4H3F3N2<\/a>)<\/p>\n<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Formula: C4H3F3N2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.<a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Formula: C4H3F3N2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[128],"class_list":["post-10475","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Moraes, Paulo A.&#039;s team published research in ChemistrySelect in 2020 | CAS: 20154-03-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Formula: C4H3F3N2In 2020 ,\u300aPyrazole-Enaminones as Promising Prototypes for the Development of Analgesic Drugs\u300b appeared in ChemistrySelect. The author of the article were Moraes, Paulo A.; Brum, Evelyne S.; Brusco, Indiara; Marangoni, Mario A.; Lobo, Marcio M.; Camargo, Adriano F.; Nogara, Pablo A.; Bonacorso, Helio G.; Martins, Marcos A. P.; Da Rocha, Joao Batista T.; Oliveira, Sara M.; Zanatta, Nilo. The article conveys some information:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10475\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Moraes, Paulo A.&#039;s team published research in ChemistrySelect in 2020 | CAS: 20154-03-4 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Formula: C4H3F3N2In 2020 ,\u300aPyrazole-Enaminones as Promising Prototypes for the Development of Analgesic Drugs\u300b appeared in ChemistrySelect. The author of the article were Moraes, Paulo A.; Brum, Evelyne S.; Brusco, Indiara; Marangoni, Mario A.; Lobo, Marcio M.; Camargo, Adriano F.; Nogara, Pablo A.; Bonacorso, Helio G.; Martins, Marcos A. P.; Da Rocha, Joao Batista T.; Oliveira, Sara M.; Zanatta, Nilo. 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The author of the article were Moraes, Paulo A.; Brum, Evelyne S.; Brusco, Indiara; Marangoni, Mario A.; Lobo, Marcio M.; Camargo, Adriano F.; Nogara, Pablo A.; Bonacorso, Helio G.; Martins, Marcos A. P.; Da Rocha, Joao Batista T.; Oliveira, Sara M.; Zanatta, Nilo. 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