{"id":10463,"date":"2022-10-21T06:58:52","date_gmt":"2022-10-20T22:58:52","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10463"},"modified":"2022-10-21T06:58:52","modified_gmt":"2022-10-20T22:58:52","slug":"graner-r-franquesas-team-published-research-in-galenica-acta-in-1959-cas-15366-34-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10463","title":{"rendered":"Graner, R. Franquesa’s team published research in Galenica Acta in 1959 | CAS: 15366-34-4"},"content":{"rendered":"

In 1959,Graner, R. Franquesa published \u300aSynthesis of 2-acetamido-5-nitrothiazole, an oral bactericide\u300b.Galenica Acta published the findings.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate<\/a> The information in the text is summarized as follows:<\/p>\n

Tech. 2-aminothiazole-HCl was purified by neutralizing with NaOH at 50\u00b0, cooling with the addition of the solid amine to prevent supercooling, washing at pH 11-12, then with a saturated solution of NaCl, and then H2O. The solid was air-dried and distilled, b12 139-43\u00b0; 65% 2-aminothiazole (I) was recovered. Preparation of 2-acetamido-5-nitrothiazole (II) (CA 46, 10285h; 40, 40583) was accomplished by acetylation, then nitration of I (78.2% over-all yield), and by the reverse steps (62.8% over-all). Ac2O (1.3 mole), 1 mole I, and 0.1 mole H2SO4 was refluxed 10 min., poured on ice, and the solid recrystallized m. 209-10\u00b0, for a 92% yield of 2-acetamidothiazole (III). III (142 g.) was dissolved in 450 ml. concentrated H2SO4 at 10\u00b0 with the addition of 46 ml. (d. 1.5) fuming HNO3 over 40 min.; allowing the temperature to reach 50\u00b0 for 30 min., pouring on ice, filtering, and washing with water, EtOH, and recrystallizing from AcOH (50 ml.\/5 g.) gave 152 g. II, m. 265-6\u00b0. I (100 g.) was dissolved in 300 ml. concentrated H2SO4 at 10\u00b0, and 46 ml. (d. 1.5) fuming HNO3 was added dropwise with agitation at 12\u00b0. The temperature was kept 3 hrs. at 0\u00b0, then at 25\u00b0 for 24 hrs. The mass was poured onto 5000 ml. icewater, and the filtrate neutralized with 600 g. Na2CO3 in 2000 ml. H2O. The product was water-washed, and recrystallized from EtOH (100 ml.\/5 g.) to give 100 g. 2-amino-5-nitrothiazole (IV), m. 202-3\u00b0. IV (7 g.), 50 ml. Ac2O, and 3 drops of concentrated H2SO4 were refluxed 7 min., and cooled to 0\u00b0. Recrystallization of the solid from AcOH gave 8.5 g. II, m. 265\u00b0. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate<\/a>)<\/p>\n

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[174,131],"tags":[128],"class_list":["post-10463","post","type-post","status-publish","format-standard","hentry","category-15366-34-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"\nGraner, R. 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