{"id":10437,"date":"2022-10-21T06:57:22","date_gmt":"2022-10-20T22:57:22","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10437"},"modified":"2022-10-21T06:57:22","modified_gmt":"2022-10-20T22:57:22","slug":"lv-shuaipengs-team-published-research-in-communications-chemistry-in-2019-cas-20154-03-4-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10437","title":{"rendered":"Lv, Shuaipeng’s team published research in Communications Chemistry in 2019 | CAS: 20154-03-4"},"content":{"rendered":"

\u300aLewis base-catalyzed intermolecular triazene alkyne cycloaddition for late-stage functionalization and scaffold diversification\u300b was written by Lv, Shuaipeng; Zhou, Hui; Yu, Xin; Xu, Yue; Zhu, Huijuan; Wang, Min; Liu, Haitao; Dai, Ziru; Sun, Guibo; Gong, Xiaojie; Sun, Xiaobo; Wang, Lei. Category: pyrazoles-derivatives<\/a>This research focused ontriazene 3 Trifluoromethylpyrazole cycloaddition Lewis base platelet aggregation inhibitor. The article conveys some information:<\/p>\n

3-Trifluoromethylpyrazole and its derivatives are of major interest to both the agrochem. and pharmaceutical industry for their diverse biol. activities. Reported routes for the synthesis of 3-trifluoromethylpyrazoles are hindered by poor regioselectivity and limited scope of application. Here we report a directed Lewis base catalyzed intermol. triazene-alkyne cycloaddition It is featured that the combination of 1,8-diazabicyclo[5.4.0]undec-7-ene and 2,2,2-trifluorodiazoethane produces reactive triazene intermediates, which readily participate in cycloaddition reactions with terminal\/internal alkynes, thus assembling densely substituted 3-trifluoromethylpyrazole scaffolds with environmental friendliness and operational simplicity. Synthetic utility of the protocol is highlighted by late-stage functionalization and scaffolds diversification. The practical value is also emphasized in potential platelet aggregation inhibitor synthesis. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Category: pyrazoles-derivatives<\/a>) was used in this study.<\/p>\n

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Category: pyrazoles-derivatives<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Category: pyrazoles-derivatives<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[128],"class_list":["post-10437","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"\nLv, Shuaipeng's team published research in Communications Chemistry in 2019 | CAS: 20154-03-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"\u300aLewis base-catalyzed intermolecular triazene alkyne cycloaddition for late-stage functionalization and scaffold diversification\u300b was written by Lv, Shuaipeng; Zhou, Hui; Yu, Xin; Xu, Yue; Zhu, Huijuan; Wang, Min; Liu, Haitao; Dai, Ziru; Sun, Guibo; Gong, Xiaojie; Sun, Xiaobo; Wang, Lei. 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