{"id":10432,"date":"2022-10-21T06:57:22","date_gmt":"2022-10-20T22:57:22","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10432"},"modified":"2022-10-21T06:57:22","modified_gmt":"2022-10-20T22:57:22","slug":"washizuka-ken-ichis-team-published-research-in-tetrahedron-letters-in-1999-cas-5952-93-2-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10432","title":{"rendered":"Washizuka, Ken-Ichi&#8217;s team published research in Tetrahedron Letters in 1999 | CAS: 5952-93-2"},"content":{"rendered":"<p>Washizuka, Ken-Ichi; Nagai, Keiko; Minakata, Satoshi; Ryu, Ilhyong; Komatsu, Mitsuo published their research in Tetrahedron Letters on December 10 ,1999. The article was titled \u300aNovel generation of azomethine imines from \u03b1-silyl nitrosamines by 1,4-silatropic shift and their cycloaddition\u300b.<a href=\"https:\/\/www.ambeed.com\/products\/5952-93-2.html\">Electric Literature of C6H8N2O2<\/a> The article contains the following contents:<\/p>\n<p>The novel and facile generation of azomethine imines from \u03b1-silyl nitrosamines and their subsequent cycloaddition with dipolarophiles leading to a variety of pyrazoles is described. The key to the reaction is a 1,4-silatropic shift caused by strong affinity of the nitroso O atom toward the Si atom. Thus, \u03b1-silyl nitrosamines are treated with 1 equivalent of dipolarophile in refluxing PhMe for 1 h to give pyrazoles in good to excellent yields. The experimental part of the paper was very detailed, including the reaction process of Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2<a href=\"https:\/\/www.ambeed.com\/products\/5952-93-2.html\">Electric Literature of C6H8N2O2<\/a>)<\/p>\n<p>Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. <a href=\"https:\/\/www.ambeed.com\/products\/5952-93-2.html\">Electric Literature of C6H8N2O2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. <a href=\"https:\/\/www.ambeed.com\/products\/5952-93-2.html\">Electric Literature of C6H8N2O2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[689,131],"tags":[128],"class_list":["post-10432","post","type-post","status-publish","format-standard","hentry","category-5952-93-2","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Washizuka, Ken-Ichi&#039;s team published research in Tetrahedron Letters in 1999 | CAS: 5952-93-2 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Washizuka, Ken-Ichi; Nagai, Keiko; Minakata, Satoshi; Ryu, Ilhyong; Komatsu, Mitsuo published their research in Tetrahedron Letters on December 10 ,1999. The article was titled \u300aNovel generation of azomethine imines from \u03b1-silyl nitrosamines by 1,4-silatropic shift and their cycloaddition\u300b.Electric Literature of C6H8N2O2 The article contains the following contents:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=10432\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Washizuka, Ken-Ichi&#039;s team published research in Tetrahedron Letters in 1999 | CAS: 5952-93-2 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Washizuka, Ken-Ichi; Nagai, Keiko; Minakata, Satoshi; Ryu, Ilhyong; Komatsu, Mitsuo published their research in Tetrahedron Letters on December 10 ,1999. The article was titled \u300aNovel generation of azomethine imines from \u03b1-silyl nitrosamines by 1,4-silatropic shift and their cycloaddition\u300b.Electric Literature of C6H8N2O2 The article contains the following contents:\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=10432\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-20T22:57:22+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=10432\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=10432\",\"name\":\"Washizuka, Ken-Ichi's team published research in Tetrahedron Letters in 1999 | CAS: 5952-93-2 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-20T22:57:22+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Washizuka, Ken-Ichi; Nagai, Keiko; Minakata, Satoshi; Ryu, Ilhyong; Komatsu, Mitsuo published their research in Tetrahedron Letters on December 10 ,1999. The article was titled \u300aNovel generation of azomethine imines from \u03b1-silyl nitrosamines by 1,4-silatropic shift and their cycloaddition\u300b.Electric Literature of C6H8N2O2 The article contains the following contents:\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=10432#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=10432\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=10432#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Washizuka, Ken-Ichi&#8217;s team published research in Tetrahedron Letters in 1999 | CAS: 5952-93-2\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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The article was titled \u300aNovel generation of azomethine imines from \u03b1-silyl nitrosamines by 1,4-silatropic shift and their cycloaddition\u300b.Electric Literature of C6H8N2O2 The article contains the following contents:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=10432","og_locale":"en_US","og_type":"article","og_title":"Washizuka, Ken-Ichi's team published research in Tetrahedron Letters in 1999 | CAS: 5952-93-2 | pyrazoles-derivatives","og_description":"Washizuka, Ken-Ichi; Nagai, Keiko; Minakata, Satoshi; Ryu, Ilhyong; Komatsu, Mitsuo published their research in Tetrahedron Letters on December 10 ,1999. The article was titled \u300aNovel generation of azomethine imines from \u03b1-silyl nitrosamines by 1,4-silatropic shift and their cycloaddition\u300b.Electric Literature of C6H8N2O2 The article contains the following contents:","og_url":"http:\/\/www.pyrazoles-derivatives.com\/?p=10432","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-10-20T22:57:22+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=10432","url":"http:\/\/www.pyrazoles-derivatives.com\/?p=10432","name":"Washizuka, Ken-Ichi's team published research in Tetrahedron Letters in 1999 | CAS: 5952-93-2 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-10-20T22:57:22+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Washizuka, Ken-Ichi; Nagai, Keiko; Minakata, Satoshi; Ryu, Ilhyong; Komatsu, Mitsuo published their research in Tetrahedron Letters on December 10 ,1999. 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