{"id":1042,"date":"2020-11-17T11:04:35","date_gmt":"2020-11-17T03:04:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1042"},"modified":"2020-11-17T11:04:35","modified_gmt":"2020-11-17T03:04:35","slug":"extended-knowledge-of-39806-90-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1042","title":{"rendered":"Extended knowledge of 39806-90-1"},"content":{"rendered":"

Adding some certain compound to certain chemical reactions, such as: 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39806-90-1. 39806-90-1<\/a><\/p>\n

To a solution of intermediate 35.8 (30 mg, 0.097 mmol) in anhydrous l,4-Dioxane (3 mL) was added 4-iodo-l-methyl-lH-pyrazole (40.3 mg, 0.194 mmol), K3PO4 (61.7 mg, 0.291 mmol), (trans)-N, N2-dimethylcy cl ohexane-l, 2-diamine (10 mg, 0.070 mmol) and Cul (5 mg, 0.026 mmol), and the resulting mixture was stirred at 90C under N2 protection for 16 hours. Afterward, the reaction was filtered and concentrated. The crude residue was purified by pre-HPLC (TFA) to give example 35.9, 5-chloro-4-fluoro-l-(l-methyl-lH-pyrazol-4-yl)-6-(l-(oxetan-3-yl)piperidin- 4-yl)-lH-indazole, TFA salt. MS (ESI) m\/z calc?d for C19H22CIFN5O [M+H]+ 390, found 390. NMR (500 MHz, CDCI3): d 8.17 (s, 1H), 8.03 (s, 1H), 7.86 (s, 1H), 7.40 (s, 1H), 5.13 (t, .7=7.17 Hz, 2H), 4.81 (m, 2H), 4.18 (m, 1H), 4.03 (s, 3H), 3.59 (m, 2H), 3.43 (m, 1H), 2.78 (m, 2H), 2.46- 2.54 (m, 2H), 2.13 (m, 2H). LRRK2 ICso 6.9 nM.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-Iodo-1-methyl-1H-pyrazole.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-Iodo-1-methyl-1H-pyrazole.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[162,131],"tags":[127],"class_list":["post-1042","post","type-post","status-publish","format-standard","hentry","category-39806-90-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nExtended knowledge of 39806-90-1<\/title>\n<meta name=\"description\" content=\"Adding some certain compound to certain chemical reactions, such as: 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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