{"id":10363,"date":"2022-10-20T04:13:53","date_gmt":"2022-10-19T20:13:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10363"},"modified":"2022-10-20T04:13:53","modified_gmt":"2022-10-19T20:13:53","slug":"zhang-yu-juans-team-published-research-in-jingxi-huagong-zhongjianti-in-2013-cas-847818-74-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10363","title":{"rendered":"Zhang, Yu-juan&#8217;s team published research in Jingxi Huagong Zhongjianti in 2013 | CAS: 847818-74-0"},"content":{"rendered":"<p>In 2013,Zhang, Yu-juan; Xing, Lei; Chen, Guo-liang published \u300aSynthesis of pinacol 1-methyl-1H-pyrazole-5-boronate\u300b.Jingxi Huagong Zhongjianti published the findings.<a href=\"https:\/\/www.ambeed.com\/products\/847818-74-0.html\">Category: pyrazoles-derivatives<\/a> The information in the text is summarized as follows:<\/p>\n<p>Alkyl-pyrazole acid is an important intermediate for the synthesis of many biol. active compounds The target compound was prepared in overall yield of 27.4% starting from 1H-pyrazole via methylation with tri-Me phosphate, converting into boronic acids with tri-Me borate after reaction with Bu lithium, and condensation with pinacol. The process conditions were optimized for the synthesis and purification of intermediate 3. The structure of target compound was characterized by 1H NMR. In the experiment, the researchers used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0<a href=\"https:\/\/www.ambeed.com\/products\/847818-74-0.html\">Category: pyrazoles-derivatives<\/a>)<\/p>\n<p>1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory,  antidiabetic and antibacterial activities. <a href=\"https:\/\/www.ambeed.com\/products\/847818-74-0.html\">Category: pyrazoles-derivatives<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory,  antidiabetic and antibacterial activities. <a href=\"https:\/\/www.ambeed.com\/products\/847818-74-0.html\">Category: pyrazoles-derivatives<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[744,131],"tags":[129],"class_list":["post-10363","post","type-post","status-publish","format-standard","hentry","category-847818-74-0","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Zhang, Yu-juan&#039;s team published research in Jingxi Huagong Zhongjianti in 2013 | CAS: 847818-74-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"In 2013,Zhang, Yu-juan; Xing, Lei; Chen, Guo-liang published \u300aSynthesis of pinacol 1-methyl-1H-pyrazole-5-boronate\u300b.Jingxi Huagong Zhongjianti published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10363\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zhang, Yu-juan&#039;s team published research in Jingxi Huagong Zhongjianti in 2013 | CAS: 847818-74-0 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"In 2013,Zhang, Yu-juan; Xing, Lei; Chen, Guo-liang published \u300aSynthesis of pinacol 1-methyl-1H-pyrazole-5-boronate\u300b.Jingxi Huagong Zhongjianti published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10363\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-19T20:13:53+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10363\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10363\",\"name\":\"Zhang, Yu-juan's team published research in Jingxi Huagong Zhongjianti in 2013 | CAS: 847818-74-0 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-19T20:13:53+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"In 2013,Zhang, Yu-juan; Xing, Lei; Chen, Guo-liang published \u300aSynthesis of pinacol 1-methyl-1H-pyrazole-5-boronate\u300b.Jingxi Huagong Zhongjianti published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10363#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10363\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10363#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Zhang, Yu-juan&#8217;s team published research in Jingxi Huagong Zhongjianti in 2013 | CAS: 847818-74-0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Zhang, Yu-juan's team published research in Jingxi Huagong Zhongjianti in 2013 | CAS: 847818-74-0 | pyrazoles-derivatives","description":"In 2013,Zhang, Yu-juan; Xing, Lei; Chen, Guo-liang published \u300aSynthesis of pinacol 1-methyl-1H-pyrazole-5-boronate\u300b.Jingxi Huagong Zhongjianti published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=10363","og_locale":"en_US","og_type":"article","og_title":"Zhang, Yu-juan's team published research in Jingxi Huagong Zhongjianti in 2013 | CAS: 847818-74-0 | pyrazoles-derivatives","og_description":"In 2013,Zhang, Yu-juan; Xing, Lei; Chen, Guo-liang published \u300aSynthesis of pinacol 1-methyl-1H-pyrazole-5-boronate\u300b.Jingxi Huagong Zhongjianti published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=10363","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-10-19T20:13:53+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=10363","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=10363","name":"Zhang, Yu-juan's team published research in Jingxi Huagong Zhongjianti in 2013 | CAS: 847818-74-0 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-10-19T20:13:53+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"In 2013,Zhang, Yu-juan; Xing, Lei; Chen, Guo-liang published \u300aSynthesis of pinacol 1-methyl-1H-pyrazole-5-boronate\u300b.Jingxi Huagong Zhongjianti published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=10363#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=10363"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=10363#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Zhang, Yu-juan&#8217;s team published research in Jingxi Huagong Zhongjianti in 2013 | CAS: 847818-74-0"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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