{"id":10352,"date":"2022-10-20T04:13:53","date_gmt":"2022-10-19T20:13:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10352"},"modified":"2022-10-20T04:13:53","modified_gmt":"2022-10-19T20:13:53","slug":"chen-lin-zhis-team-published-research-in-journal-of-organic-chemistry-in-1991-cas-52096-24-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10352","title":{"rendered":"Chen, Lin Zhi&#8217;s team published research in Journal of Organic Chemistry in 1991 | CAS: 52096-24-9"},"content":{"rendered":"<p>Chen, Lin Zhi; Flammang, Robert; Maquestiau, Andre; Taft, Robert W.; Catalan, Javier; Cabildo, Pilar; Claramunt, Rosa M.; Elguero, Jose published an article on January 4 ,1991. The article was titled \u300aThermodynamic basicity vs. kinetic basicity of diazoles (imidazoles and pyrazoles)\u300b, and you may find the article in Journal of Organic Chemistry.<a href=\"https:\/\/www.ambeed.com\/products\/52096-24-9.html\">Electric Literature of C7H12N2<\/a> The information in the text is summarized as follows:<\/p>\n<p>The intrinsic basicity of 24 azoles (pyrazoles, indazoles, imidazoles, benzimidazoles) and 7-methylazaindole was determined by mass spectrometry techniques, ion cyclotron resonance (ICR), and\/or chem. ionization (CI) in conjunction with tandem mass spectrometry (MS\/MS). A reasonably good agreement (r2 = 0.967) is found between both methods (15 compounds). Thus, it is possible to use CI\/MS\/MS to determine the intrinsic basicity of compounds not measurable by ICR for purity or volatility reasons. Some anomalies are interpreted in terms of entropy and steric effects. The basicity data are also discussed by using empirical models (\u03c3\u03b1, \u03c3R) and chelation and annelation effects. The results came from multiple reactions, including the reaction of 1-Butyl-1H-pyrazole(cas: 52096-24-9<a href=\"https:\/\/www.ambeed.com\/products\/52096-24-9.html\">Electric Literature of C7H12N2<\/a>)<\/p>\n<p>1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. <a href=\"https:\/\/www.ambeed.com\/products\/52096-24-9.html\">Electric Literature of C7H12N2<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. <a href=\"https:\/\/www.ambeed.com\/products\/52096-24-9.html\">Electric Literature of C7H12N2<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[687,131],"tags":[128],"class_list":["post-10352","post","type-post","status-publish","format-standard","hentry","category-52096-24-9","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Chen, Lin Zhi&#039;s team published research in Journal of Organic Chemistry in 1991 | CAS: 52096-24-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Chen, Lin Zhi; Flammang, Robert; Maquestiau, Andre; Taft, Robert W.; Catalan, Javier; Cabildo, Pilar; Claramunt, Rosa M.; Elguero, Jose published an article on January 4 ,1991. The article was titled \u300aThermodynamic basicity vs. kinetic basicity of diazoles (imidazoles and pyrazoles)\u300b, and you may find the article in Journal of Organic Chemistry.Electric Literature of C7H12N2 The information in the text is summarized as follows:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10352\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chen, Lin Zhi&#039;s team published research in Journal of Organic Chemistry in 1991 | CAS: 52096-24-9 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Chen, Lin Zhi; Flammang, Robert; Maquestiau, Andre; Taft, Robert W.; Catalan, Javier; Cabildo, Pilar; Claramunt, Rosa M.; Elguero, Jose published an article on January 4 ,1991. The article was titled \u300aThermodynamic basicity vs. kinetic basicity of diazoles (imidazoles and pyrazoles)\u300b, and you may find the article in Journal of Organic Chemistry.Electric Literature of C7H12N2 The information in the text is summarized as follows:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10352\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-19T20:13:53+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10352\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10352\",\"name\":\"Chen, Lin Zhi's team published research in Journal of Organic Chemistry in 1991 | CAS: 52096-24-9 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-19T20:13:53+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Chen, Lin Zhi; Flammang, Robert; Maquestiau, Andre; Taft, Robert W.; Catalan, Javier; Cabildo, Pilar; Claramunt, Rosa M.; Elguero, Jose published an article on January 4 ,1991. The article was titled \u300aThermodynamic basicity vs. kinetic basicity of diazoles (imidazoles and pyrazoles)\u300b, and you may find the article in Journal of Organic Chemistry.Electric Literature of C7H12N2 The information in the text is summarized as follows:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10352#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10352\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10352#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Chen, Lin Zhi&#8217;s team published research in Journal of Organic Chemistry in 1991 | CAS: 52096-24-9\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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