{"id":1033,"date":"2020-11-16T10:15:25","date_gmt":"2020-11-16T02:15:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1033"},"modified":"2020-11-16T10:15:25","modified_gmt":"2020-11-16T02:15:25","slug":"new-learning-discoveries-about-288-13-1-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1033","title":{"rendered":"New learning discoveries about 288-13-1"},"content":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 288-13-1, name is 1H-Pyrazole, I believe this compound will play a more active role in future production and life. 288-13-1<\/a><\/p>\n

Following General Procedure A (90 0C, 30 hours), 1H-pyrazole (205 mg, 3.0 mmol) is coupled with 1-(4-bromophenyl)ethanone (398 mg, 2.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane\/hexanes = 50\/50) to provide 300 mg (81 % isolated yield) of the desired product as a white solid. IdentificationMp: 108 JOC.1H NMR (400 MHz, CDCI3): delta 7.98-8.00 (m, 3H, H3|5,7), 7.70-7.76 (m, 3H, H2>6.9), 6.46 (s, 1H, H8), 2.56 (s, 3H, H11).13C NMR (100 MHz, CDCI3): delta 196.84 (C10), 143.33 (C1), 142.09 (C9), 134.80 (C4), 130.01 (C3,beta), 126.91 (C7), 118.39 (C216), 108.62 (C8), 26.60 (C11).IR (KBr) : v (crrf1) = 3135, 3114, 3101 , 1673(C=O), 1605, 1528, 1395, 1264,1210, 935, 838, 762, 611 , 589, 518.GC\/MS: rt = 19.96 min, M\/Z = 186.HRMS: 187.0893 (M+H). Theoretical: 187.0871.<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 288-13-1. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 288-13-1. 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