{"id":10325,"date":"2022-10-20T02:42:42","date_gmt":"2022-10-19T18:42:42","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10325"},"modified":"2022-10-20T02:42:42","modified_gmt":"2022-10-19T18:42:42","slug":"machado-antonio-ss-team-published-research-in-current-organic-synthesis-in-2021-12-31-13788-92-6-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10325","title":{"rendered":"Machado, Antonio S’s team published research in Current Organic Synthesis in 2021-12-31 | 13788-92-6"},"content":{"rendered":"

Machado, Antonio S.; de Carvalho, Flavio S.; Mouraa, Rayssa B. P.; Chaves, Lorrayne S.; Liao, Luciano M.; Sanz, German; Vaz, Boniek G.; Rodrigues, Marcella F.; Romao, Wanderson; Menegatti, Ricardo; Silva, Gloria N. S. published the artcile< Comparison of Conventional and Microwave Synthesis of Phenyl-1H-pyrazoles and Phenyl-1H-pyrazoles-4-carboxylic Acid Derivatives>, Name: 1-(4-Bromophenyl)-1H-pyrazole<\/a>, the main research area is carboxylic acid phenyl pyrazole preparation green chem microwave irradiation; carbaldehyde phenyl pyrazole oxidation; phenyl pyrazole preparation green chem microwave irradiation; phenylhydrazine tetramethoxypropane heterocyclization; Pyrazole; conventional heating; heterocycle; microwave irradiation.; privileged scaffolds; synthesis.<\/p>\n

The purpose of this study was the optimization of the conventional synthesis of the pyrazole rings I (R1 = H) and the oxidation of phenyl-1H-pyrazole-4-carbaldehydes I (R = H, 2-Cl, 3-Br, 4-CF3, etc.; R1 = CHO) to phenyl-1H-pyrazole-4-carboxylic acids I (R1 = COOH) through Microwave- Assisted Organic Synthesis (MAOS). A comparison between conventional synthesis and conventional synthesis with microwave heating using the synthesis method of pyrazole ring described by Finar and Godfrey and for the oxidation of phenyl-1H-pyrazole-4-carbaldehyde, and the method described by Shriner and Kleiderer was used. MAOS reduces the reaction time to obtain all compounds compared to conventional heating. At a temperature of 60\u00b0C, 5 min of reaction time, and power of 50 W, the yield of phenyl-1H-pyrazoles I (R1 = H) was in the range of 91 – 98% using MAOS, which is better than conventional heating (72 – 90%, 75\u00b0C, 2 h). An improvement in the yield for the oxidation reaction was also achieved with MAOS. The compounds I (R1 = COOH) were obtained with yields ranging from 62 – 92% (80\u00b0C, 2 min, 150 W), while the yields with conventional heating were in the range of 48 – 85% (80\u00b0C, 1 h). The 26 compounds I were achieved through an easy work-up procedure with no chromatog. separation<\/p>\n

Current Organic Synthesis published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Name: 1-(4-Bromophenyl)-1H-pyrazole<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Current Organic Synthesis published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Name: 1-(4-Bromophenyl)-1H-pyrazole<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[738,131],"tags":[716],"class_list":["post-10325","post","type-post","status-publish","format-standard","hentry","category-13788-92-6","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nMachado, Antonio S's team published research in Current Organic Synthesis in 2021-12-31 | 13788-92-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Machado, Antonio S.; de Carvalho, Flavio S.; Mouraa, Rayssa B. P.; Chaves, Lorrayne S.; Liao, Luciano M.; Sanz, German; Vaz, Boniek G.; Rodrigues, Marcella F.; Romao, Wanderson; Menegatti, Ricardo; Silva, Gloria N. S. published the artcile< Comparison of Conventional and Microwave Synthesis of Phenyl-1H-pyrazoles and Phenyl-1H-pyrazoles-4-carboxylic Acid Derivatives>, Name: 1-(4-Bromophenyl)-1H-pyrazole, the main research area is carboxylic acid phenyl pyrazole preparation green chem microwave irradiation; carbaldehyde phenyl pyrazole oxidation; phenyl pyrazole preparation green chem microwave irradiation; phenylhydrazine tetramethoxypropane heterocyclization; Pyrazole; conventional heating; heterocycle; microwave irradiation.; privileged scaffolds; synthesis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=10325\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Machado, Antonio S's team published research in Current Organic Synthesis in 2021-12-31 | 13788-92-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Machado, Antonio S.; de Carvalho, Flavio S.; Mouraa, Rayssa B. P.; Chaves, Lorrayne S.; Liao, Luciano M.; Sanz, German; Vaz, Boniek G.; Rodrigues, Marcella F.; Romao, Wanderson; Menegatti, Ricardo; Silva, Gloria N. S. published the artcile< Comparison of Conventional and Microwave Synthesis of Phenyl-1H-pyrazoles and Phenyl-1H-pyrazoles-4-carboxylic Acid Derivatives>, Name: 1-(4-Bromophenyl)-1H-pyrazole, the main research area is carboxylic acid phenyl pyrazole preparation green chem microwave irradiation; carbaldehyde phenyl pyrazole oxidation; phenyl pyrazole preparation green chem microwave irradiation; phenylhydrazine tetramethoxypropane heterocyclization; Pyrazole; conventional heating; heterocycle; microwave irradiation.; privileged scaffolds; synthesis.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=10325\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-19T18:42:42+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=10325\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=10325\",\"name\":\"Machado, Antonio S's team published research in Current Organic Synthesis in 2021-12-31 | 13788-92-6 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-19T18:42:42+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Machado, Antonio S.; de Carvalho, Flavio S.; Mouraa, Rayssa B. 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