{"id":10318,"date":"2022-10-20T02:41:59","date_gmt":"2022-10-19T18:41:59","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10318"},"modified":"2022-10-20T02:41:59","modified_gmt":"2022-10-19T18:41:59","slug":"ochiai-hiroshis-team-published-research-in-chemical-pharmaceutical-bulletin-in-2004-09-30-118430-74-3-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10318","title":{"rendered":"Ochiai, Hiroshi&#8217;s team published research in Chemical &#038; Pharmaceutical Bulletin  in 2004-09-30 | 118430-74-3"},"content":{"rendered":"<p>Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Yamamoto, Susumu; Takeda, Hiroshi; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki published the artcile< Discovery of new orally active phosphodiesterase (PDE4) inhibitors>,  <a href=\"https:\/\/www.ambeed.com\/products\/118430-74-3.html\">COA of Formula: C7H11N3<\/a>,  the main research area is  phosphodiesterase PDE4 inhibitor discovery oral antiinflammatory; anilinopyrazolopyridine derivative preparation PDE4 inhibiting structure subtype selectivity.<\/p>\n<p>A series of 4-anilinopyrazolopyridine derivatives were synthesized and biol. evaluated as inhibitors of phosphodiesterase (PDE4). Chem. modification of 3, a structurally new chem. lead that was found in our inhouse library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chem. lead 5 are presented. Structure-activity relationship data, pharmacol. evaluation, and the subtype selectivity study are also presented.<\/p>\n<p>Chemical &#038; Pharmaceutical Bulletin published new progress about Anti-inflammatory agents. 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, <a href=\"https:\/\/www.ambeed.com\/products\/118430-74-3.html\">COA of Formula: C7H11N3<\/a>.<\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chemical &#038; Pharmaceutical Bulletin published new progress about Anti-inflammatory agents. 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, <a href=\"https:\/\/www.ambeed.com\/products\/118430-74-3.html\">COA of Formula: C7H11N3<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[233,131],"tags":[732],"class_list":["post-10318","post","type-post","status-publish","format-standard","hentry","category-118430-74-3","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ochiai, Hiroshi&#039;s team published research in Chemical &amp; 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Pharmaceutical Bulletin in 2004-09-30 | 118430-74-3 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Yamamoto, Susumu; Takeda, Hiroshi; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki published the artcile&lt; Discovery of new orally active phosphodiesterase (PDE4) inhibitors&gt;, COA of Formula: C7H11N3, the main research area is phosphodiesterase PDE4 inhibitor discovery oral antiinflammatory; anilinopyrazolopyridine derivative preparation PDE4 inhibiting structure subtype selectivity.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10318\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-19T18:41:59+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10318\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10318\",\"name\":\"Ochiai, Hiroshi's team published research in Chemical & Pharmaceutical Bulletin in 2004-09-30 | 118430-74-3 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-19T18:41:59+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Yamamoto, Susumu; Takeda, Hiroshi; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki published the artcile< Discovery of new orally active phosphodiesterase (PDE4) inhibitors>, COA of Formula: C7H11N3, the main research area is phosphodiesterase PDE4 inhibitor discovery oral antiinflammatory; anilinopyrazolopyridine derivative preparation PDE4 inhibiting structure subtype selectivity.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10318#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10318\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10318#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ochiai, Hiroshi&#8217;s team published research in Chemical &#038; 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