{"id":1029,"date":"2020-11-16T10:15:25","date_gmt":"2020-11-16T02:15:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1029"},"modified":"2020-11-16T10:15:25","modified_gmt":"2020-11-16T02:15:25","slug":"some-tips-on-1h-pyrazol-4-ylmethanol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1029","title":{"rendered":"Some tips on (1H-Pyrazol-4-yl)methanol"},"content":{"rendered":"

25222-43-9<\/a>, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below.<\/p>\n

(11H-Pyrazol-4-yl) methanol was Boc-protected by reaction with Boc-anhydride (1 .2 eq) and triethylamine (2.5 eq) in DCM at 0 \u00a1\u00e3C, with warming to ambient temperature. The alcohol of this Boc-protected amine was then converted to the mesylate by reaction with methanesulfonyl chloride (1 .5 eq) and triethylamine (2.5 eq) in DCM at 0 \u00a1\u00e3C, with warming to ambient temperature for 2 h. N-[1 -(Fluoromethyl)cyclopropyl]-3-[(1 -methylpyrazol-4- yl)methyl]-2,4-dioxo-1 H-quinazoline-6-sulfonamide (100 mg, 0.260 mmol), the mesylate (79 mg, 0.286 mmol) and potassium carbonate (54 mg, 0.39 mmol) in DMF was conventionally heated to 70 \u00a1\u00e3C for 4 h. After Boc-deprotection with HCI in dioxane, usual work-up afforded the desired product (14 mg, 0.029 mmol, 1 1 percent) as a white powder.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[146,131],"tags":[145],"class_list":["post-1029","post","type-post","status-publish","format-standard","hentry","category-25222-43-9","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSome tips on (1H-Pyrazol-4-yl)methanol<\/title>\n<meta name=\"description\" content=\"25222-43-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Some tips on (1H-Pyrazol-4-yl)methanol","description":"25222-43-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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