{"id":10281,"date":"2022-10-20T01:52:11","date_gmt":"2022-10-19T17:52:11","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10281"},"modified":"2022-10-20T01:52:11","modified_gmt":"2022-10-19T17:52:11","slug":"chowdhury-sarwats-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-2013-03-15-936250-20-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10281","title":{"rendered":"Chowdhury, Sarwat’s team published research in Bioorganic & Medicinal Chemistry Letters in 2013-03-15 | 936250-20-3"},"content":{"rendered":"

Chowdhury, Sarwat; Chen, Yen Ting; Fang, Xingang; Grant, Wayne; Pocas, Jennifer; Cameron, Michael D.; Ruiz, Claudia; Lin, Li; Park, HaJeung; Schroter, Thomas; Bannister, Thomas D.; LoGrasso, Philip V.; Feng, Yangbo published the artcile< Amino acid derived quinazolines as Rock\/PKA inhibitors>, Name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole<\/a>, the main research area is amino acid derived quinazolinone Rock PKA inhibitor.<\/p>\n

SAR and lead optimization studies for Rock inhibitors based on amino acid-derived quinazolines are described. Studies demonstrated that these amino acid derived quinazolinones were mainly puromycin aminonucleoside (PAN)-Rho-associated protein kinase (Rock) (I & II) inhibitors. While selectivity against other kinases could be achieved, selectivity for most of these compounds against PKA was not achieved. This is distinct from Rock inhibitors based on non-amino acid derived quinazolinones, where high selectivity against PKA could be obtained.22 The inhibitors presented here in some cases possessed sub-nanomolar inhibition of Rock, nanomolar potency in ppMLC cell based assays, low to fair cytochrome P 450 inhibition, and good human microsomal stability.<\/p>\n

Bioorganic & Medicinal Chemistry Letters published new progress about Heteroarylation (Suzuki). 936250-20-3 belongs to class pyrazoles-derivatives, and the molecular formula is C10H17BN2O2, Name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Bioorganic & Medicinal Chemistry Letters published new progress about Heteroarylation (Suzuki). 936250-20-3 belongs to class pyrazoles-derivatives, and the molecular formula is C10H17BN2O2, Name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[736,131],"tags":[716],"class_list":["post-10281","post","type-post","status-publish","format-standard","hentry","category-936250-20-3","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nChowdhury, Sarwat's team published research in Bioorganic & Medicinal Chemistry Letters in 2013-03-15 | 936250-20-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Chowdhury, Sarwat; Chen, Yen Ting; Fang, Xingang; Grant, Wayne; Pocas, Jennifer; Cameron, Michael D.; Ruiz, Claudia; Lin, Li; Park, HaJeung; Schroter, Thomas; Bannister, Thomas D.; LoGrasso, Philip V.; Feng, Yangbo published the artcile< Amino acid derived quinazolines as Rock\/PKA inhibitors>, Name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, the main research area is amino acid derived quinazolinone Rock PKA inhibitor.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10281\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chowdhury, Sarwat's team published research in Bioorganic & Medicinal Chemistry Letters in 2013-03-15 | 936250-20-3 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Chowdhury, Sarwat; Chen, Yen Ting; Fang, Xingang; Grant, Wayne; Pocas, Jennifer; Cameron, Michael D.; Ruiz, Claudia; Lin, Li; Park, HaJeung; Schroter, Thomas; Bannister, Thomas D.; LoGrasso, Philip V.; Feng, Yangbo published the artcile< Amino acid derived quinazolines as Rock\/PKA inhibitors>, Name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, the main research area is amino acid derived quinazolinone Rock PKA inhibitor.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10281\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-19T17:52:11+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10281\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10281\",\"name\":\"Chowdhury, Sarwat's team published research in Bioorganic & Medicinal Chemistry Letters in 2013-03-15 | 936250-20-3 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-19T17:52:11+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Chowdhury, Sarwat; Chen, Yen Ting; Fang, Xingang; Grant, Wayne; Pocas, Jennifer; Cameron, Michael D.; Ruiz, Claudia; Lin, Li; Park, HaJeung; Schroter, Thomas; Bannister, Thomas D.; LoGrasso, Philip V.; Feng, Yangbo published the artcile< Amino acid derived quinazolines as Rock\/PKA inhibitors>, Name: 3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, the main research area is amino acid derived quinazolinone Rock PKA inhibitor.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10281#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10281\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10281#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Chowdhury, Sarwat’s team published research in Bioorganic & Medicinal Chemistry Letters in 2013-03-15 | 936250-20-3\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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