{"id":1028,"date":"2020-11-16T10:15:25","date_gmt":"2020-11-16T02:15:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1028"},"modified":"2020-11-16T10:15:25","modified_gmt":"2020-11-16T02:15:25","slug":"sources-of-common-compounds-3-methylpyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1028","title":{"rendered":"Sources of common compounds: 3-Methylpyrazole"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1453-58-3, name is 3-Methylpyrazole, A new synthetic method of this compound is introduced below., 1453-58-3<\/a><\/p>\n

10298] To a solution of 3-methyl-1H-pyrazole (10.99 g, 134 mmol) in N,N-dimethylformamide (100 ml) at 0\u00a1\u00e3 C. was added sodium hydride (3.71 g, 154 mmol, 60percent dispersion). The reaction was stirred at 0\u00a1\u00e3C. for2 hours. 3-Fluoropyridine (10.0 g, 103 mmol) was added, and the reaction was stirred at 100\u00a1\u00e3 C. overnight. The reaction was cooled to room temperature and water was added slowly. The mixture was extracted with dichloromethane and the combined organic phases were washed with brine, concentrated and chromatographed (0-100percent ethyl acetate\/hexanes) to afford 3-(3-methyl-1H- pyrazol-1-yl)pyridine (8.4 g, 52.77 mmol, 5 1.2percent) and 3-(5- methyl-i H-pyrazol- 1 -yl)pyridine (1.0 g, 6percent). Analytical data of both products is consistent with that reported under Example 6, Step 1.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[175,131],"tags":[145],"class_list":["post-1028","post","type-post","status-publish","format-standard","hentry","category-1453-58-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSources of common compounds: 3-Methylpyrazole<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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