{"id":10248,"date":"2022-10-19T01:46:33","date_gmt":"2022-10-18T17:46:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10248"},"modified":"2022-10-19T01:46:33","modified_gmt":"2022-10-18T17:46:33","slug":"caliskan-burcus-team-published-research-in-medicinal-chemistry-research-in-2013-cas-192701-73-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10248","title":{"rendered":"Caliskan, Burcu&#8217;s team published research in Medicinal Chemistry Research in 2013 | CAS: 192701-73-8"},"content":{"rendered":"<p>Caliskan, Burcu; Yilmaz, Akin; Evren, Ilker; Menevse, Sevda; Uludag, Orhan; Banoglu, Erden published an article on February 28 ,2013. The article was titled \u300aSynthesis and evaluation of analgesic, anti-inflammatory, and anticancer activities of new pyrazole-3(5)-carboxylic acid derivatives\u300b, and you may find the article in Medicinal Chemistry Research.<a href=\"https:\/\/www.ambeed.com\/products\/192701-73-8.html\">Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate<\/a> The information in the text is summarized as follows:<\/p>\n<p>1-Benzyl-5(3)-p-tolyl-1H-pyrazole-3(5)-carboxylic acid derivatives were prepared and characterized by IR, 1H NMR, and mass spectroscopy. Compounds were evaluated for their in vivo analgesic and anti-inflammatory activity using the p-benzoquinone-induced writhing test and the carrageenan-induced paw edema model, resp. Out of 14 compounds tested, exhibited potent analgesic and\/or anti-inflammatory activity as compared to reference drugs aspirin and indomethacin. Anticancer activity of these compounds was assessed against five cancer cell lines with the MTT assay (HL-60, human promyelocytic leukemia cells; HeLa, human cervical cancer cells; Raji, human B lymphocyte cell line; MCF7, human breast adenocarcinoma cell line; MDA-MB-231, estrogen-independent human breast cancer cell line). Three compounds with high anti-inflammatory activity, and also two compounds with mild anti-inflammatory activity exhibited promising anticancer activity against some selected cell lines. In addition to this study using Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate, there are many other studies that have used Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate(cas: 192701-73-8<a href=\"https:\/\/www.ambeed.com\/products\/192701-73-8.html\">Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate<\/a>) was used in this study.<\/p>\n<p>Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate(cas: 192701-73-8) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. <a href=\"https:\/\/www.ambeed.com\/products\/192701-73-8.html\">Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate(cas: 192701-73-8) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. <a href=\"https:\/\/www.ambeed.com\/products\/192701-73-8.html\">Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[516,131],"tags":[129],"class_list":["post-10248","post","type-post","status-publish","format-standard","hentry","category-192701-73-8","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Caliskan, Burcu&#039;s team published research in Medicinal Chemistry Research in 2013 | CAS: 192701-73-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Caliskan, Burcu; Yilmaz, Akin; Evren, Ilker; Menevse, Sevda; Uludag, Orhan; Banoglu, Erden published an article on February 28 ,2013. The article was titled \u300aSynthesis and evaluation of analgesic, anti-inflammatory, and anticancer activities of new pyrazole-3(5)-carboxylic acid derivatives\u300b, and you may find the article in Medicinal Chemistry Research.Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate The information in the text is summarized as follows:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10248\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Caliskan, Burcu&#039;s team published research in Medicinal Chemistry Research in 2013 | CAS: 192701-73-8 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Caliskan, Burcu; Yilmaz, Akin; Evren, Ilker; Menevse, Sevda; Uludag, Orhan; Banoglu, Erden published an article on February 28 ,2013. The article was titled \u300aSynthesis and evaluation of analgesic, anti-inflammatory, and anticancer activities of new pyrazole-3(5)-carboxylic acid derivatives\u300b, and you may find the article in Medicinal Chemistry Research.Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate The information in the text is summarized as follows:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10248\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-18T17:46:33+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10248\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10248\",\"name\":\"Caliskan, Burcu's team published research in Medicinal Chemistry Research in 2013 | CAS: 192701-73-8 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-18T17:46:33+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Caliskan, Burcu; Yilmaz, Akin; Evren, Ilker; Menevse, Sevda; Uludag, Orhan; Banoglu, Erden published an article on February 28 ,2013. The article was titled \u300aSynthesis and evaluation of analgesic, anti-inflammatory, and anticancer activities of new pyrazole-3(5)-carboxylic acid derivatives\u300b, and you may find the article in Medicinal Chemistry Research.Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate The information in the text is summarized as follows:\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10248#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=10248\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10248#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Caliskan, Burcu&#8217;s team published research in Medicinal Chemistry Research in 2013 | CAS: 192701-73-8\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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