{"id":10247,"date":"2022-10-19T01:46:33","date_gmt":"2022-10-18T17:46:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10247"},"modified":"2022-10-19T01:46:33","modified_gmt":"2022-10-18T17:46:33","slug":"kroth-heikos-team-published-research-in-journal-of-biological-chemistry-in-2012-cas-192701-73-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10247","title":{"rendered":"Kroth, Heiko’s team published research in Journal of Biological Chemistry in 2012 | CAS: 192701-73-8"},"content":{"rendered":"

In 2012,Journal of Biological Chemistry included an article by Kroth, Heiko; Ansaloni, Annalisa; Varisco, Yvan; Jan, Asad; Sreenivasachary, Nampally; Rezaei-Ghaleh, Nasrollah; Giriens, Valerie; Lohmann, Sophie; Lopez-Deber, Maria Pilar; Adolfsson, Oskar; Pihlgren, Maria; Paganetti, Paolo; Froestl, Wolfgang; Nagel-Steger, Luitgard; Willbold, Dieter; Schrader, Thomas; Zweckstetter, Markus; Pfeifer, Andrea; Lashuel, Hilal A.; Muhs, Andreas. Recommanded Product: 192701-73-8<\/a>. The article was titled \u300aDiscovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic \u03b2-Amyloid-42 Fibril Formation\u300b. The information in the text is summarized as follows:<\/p>\n

Increasing evidence implicates A\u03b2 peptides self-assembly and fibril formation as crucial events in the pathogenesis of Alzheimer disease. Thus, inhibiting A\u03b2 aggregation, among others, has emerged as a potential therapeutic intervention for this disorder. Herein, we employed 3-aminopyrazole as a key fragment in our design of non-dye compounds capable of interacting with A\u03b242 via a donor-acceptor-donor hydrogen bond pattern complementary to that of the \u03b2-sheet conformation of A\u03b242. The initial design of the compounds was based on connecting two 3-aminopyrazole moieties via a linker to identify suitable scaffold mols. Addnl. aryl substitutions on the two 3-aminopyrazole moieties were also explored to enhance \u03c0-\u03c0 stacking\/hydrophobic interactions with amino acids of A\u03b242. The efficacy of these compounds on inhibiting A\u03b2 fibril formation and toxicity in vitro was assessed using a combination of biophys. techniques and viability assays. Using structure activity relationship data from the in vitro assays, we identified compounds capable of preventing pathol. self-assembly of A\u03b242 leading to decreased cell toxicity. In the experiment, the researchers used many compounds, for example, Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate(cas: 192701-73-8Recommanded Product: 192701-73-8<\/a>)<\/p>\n

Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate(cas: 192701-73-8) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Recommanded Product: 192701-73-8<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate(cas: 192701-73-8) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Recommanded Product: 192701-73-8<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[516,131],"tags":[129],"class_list":["post-10247","post","type-post","status-publish","format-standard","hentry","category-192701-73-8","category-pyrazoles-derivatives","tag-200-300"],"yoast_head":"\nKroth, Heiko's team published research in Journal of Biological Chemistry in 2012 | CAS: 192701-73-8 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"In 2012,Journal of Biological Chemistry included an article by Kroth, Heiko; Ansaloni, Annalisa; Varisco, Yvan; Jan, Asad; Sreenivasachary, Nampally; Rezaei-Ghaleh, Nasrollah; Giriens, Valerie; Lohmann, Sophie; Lopez-Deber, Maria Pilar; Adolfsson, Oskar; Pihlgren, Maria; Paganetti, Paolo; Froestl, Wolfgang; Nagel-Steger, Luitgard; Willbold, Dieter; Schrader, Thomas; Zweckstetter, Markus; Pfeifer, Andrea; Lashuel, Hilal A.; Muhs, Andreas. Recommanded Product: 192701-73-8. The article was titled \u300aDiscovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic \u03b2-Amyloid-42 Fibril Formation\u300b. 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Recommanded Product: 192701-73-8. The article was titled \u300aDiscovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic \u03b2-Amyloid-42 Fibril Formation\u300b. 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