{"id":10246,"date":"2022-10-19T01:46:33","date_gmt":"2022-10-18T17:46:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=10246"},"modified":"2022-10-19T01:46:33","modified_gmt":"2022-10-18T17:46:33","slug":"osullivan-leonies-team-published-research-in-journal-of-organic-chemistry-in-2022-cas-930-36-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=10246","title":{"rendered":"O&#8217;Sullivan, Leonie&#8217;s team published research in Journal of Organic Chemistry in 2022 | CAS: 930-36-9"},"content":{"rendered":"<p>O&#8217;Sullivan, Leonie; Patel, Ketul V.; Rowley, Ben C.; Brownsey, Duncan K.; Gorobets, Evgueni; Gelfand, Benjamin S.; Van Humbeck, Jeffrey F.; Derksen, Darren J. published an article on January 7 ,2022. The article was titled \u300aRegioselective Synthesis of C3-Hydroxyarylated Pyrazoles\u300b, and you may find the article in Journal of Organic Chemistry.<a href=\"https:\/\/www.ambeed.com\/products\/930-36-9.html\">Product Details of 930-36-9<\/a> The information in the text is summarized as follows:<\/p>\n<p>The first regioselective route to C3-hydroxyarylated pyrazoles obtained through reaction of pyrazole N-oxides with arynes using mild conditions is reported. Importantly, this method does not require the C4 and C5 positions of the pyrazole to be functionalized to observe regioselectivity. Using this method, authors completed the synthesis of a recently reported JAK 1\/2 inhibitor. Authors&#8217; synthesis produces the desired product in 4 steps from com. available starting materials. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9<a href=\"https:\/\/www.ambeed.com\/products\/930-36-9.html\">Product Details of 930-36-9<\/a>)<\/p>\n<p>1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. <a href=\"https:\/\/www.ambeed.com\/products\/930-36-9.html\">Product Details of 930-36-9<\/a><\/p>\n<p>Referemce:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. <a href=\"https:\/\/www.ambeed.com\/products\/930-36-9.html\">Product Details of 930-36-9<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[245,131],"tags":[743],"class_list":["post-10246","post","type-post","status-publish","format-standard","hentry","category-930-36-9","category-pyrazoles-derivatives","tag-0-100"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>O&#039;Sullivan, Leonie&#039;s team published research in Journal of Organic Chemistry in 2022 | CAS: 930-36-9 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"O&#039;Sullivan, Leonie; Patel, Ketul V.; Rowley, Ben C.; Brownsey, Duncan K.; Gorobets, Evgueni; Gelfand, Benjamin S.; Van Humbeck, Jeffrey F.; Derksen, Darren J. published an article on January 7 ,2022. The article was titled \u300aRegioselective Synthesis of C3-Hydroxyarylated Pyrazoles\u300b, and you may find the article in Journal of Organic Chemistry.Product Details of 930-36-9 The information in the text is summarized as follows:\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10246\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"O&#039;Sullivan, Leonie&#039;s team published research in Journal of Organic Chemistry in 2022 | CAS: 930-36-9 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"O&#039;Sullivan, Leonie; Patel, Ketul V.; Rowley, Ben C.; Brownsey, Duncan K.; Gorobets, Evgueni; Gelfand, Benjamin S.; Van Humbeck, Jeffrey F.; Derksen, Darren J. published an article on January 7 ,2022. The article was titled \u300aRegioselective Synthesis of C3-Hydroxyarylated Pyrazoles\u300b, and you may find the article in Journal of Organic Chemistry.Product Details of 930-36-9 The information in the text is summarized as follows:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=10246\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-18T17:46:33+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10246\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=10246\",\"name\":\"O'Sullivan, Leonie's team published research in Journal of Organic Chemistry in 2022 | CAS: 930-36-9 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-18T17:46:33+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"O'Sullivan, Leonie; Patel, Ketul V.; Rowley, Ben C.; Brownsey, Duncan K.; Gorobets, Evgueni; Gelfand, Benjamin S.; Van Humbeck, Jeffrey F.; Derksen, Darren J. published an article on January 7 ,2022. 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The article was titled \u300aRegioselective Synthesis of C3-Hydroxyarylated Pyrazoles\u300b, and you may find the article in Journal of Organic Chemistry.Product Details of 930-36-9 The information in the text is summarized as follows:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=10246","og_locale":"en_US","og_type":"article","og_title":"O'Sullivan, Leonie's team published research in Journal of Organic Chemistry in 2022 | CAS: 930-36-9 | pyrazoles-derivatives","og_description":"O'Sullivan, Leonie; Patel, Ketul V.; Rowley, Ben C.; Brownsey, Duncan K.; Gorobets, Evgueni; Gelfand, Benjamin S.; Van Humbeck, Jeffrey F.; Derksen, Darren J. published an article on January 7 ,2022. 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